InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Got1

Summary

InnateDB Protein

IDBP-168156.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Got1

Protein Name

glutamate oxaloacetate transaminase 1, soluble

Synonyms

AI789014; cAspAT; cCAT; Got-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026196

InnateDB Gene

IDBG-168154 (Got1)

Protein Structure

UniProt Annotation

Function

Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in neurons of the retina. Localizes to the inner and outer plexiform layers, the inner and outer nuclear layer and the outer segments of photoreceptors. {ECO:0000269PubMed:21937432}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity
GO:0004609	phosphatidylserine decarboxylase activity
GO:0030170	pyridoxal phosphate binding
GO:0031406	carboxylic acid binding
GO:0047801	L-cysteine:2-oxoglutarate aminotransferase activity
GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity

Biological Process

GO:0006103	2-oxoglutarate metabolic process
GO:0006107	oxaloacetate metabolic process
GO:0006114	glycerol biosynthetic process
GO:0006531	aspartate metabolic process
GO:0006532	aspartate biosynthetic process
GO:0006533	aspartate catabolic process
GO:0006536	glutamate metabolic process
GO:0009058	biosynthetic process
GO:0019550	glutamate catabolic process to aspartate
GO:0019551	glutamate catabolic process to 2-oxoglutarate
GO:0032869	cellular response to insulin stimulus
GO:0043648	dicarboxylic acid metabolic process
GO:0051384	response to glucocorticoid
GO:0055089	fatty acid homeostasis