InnateDB Protein
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IDBP-154558.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Whsc2
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Protein Name
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Wolf-Hirschhorn syndrome candidate 2 (human)
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Synonyms
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Whsc2; Whsc2h;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000030993
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InnateDB Gene
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IDBG-154556 (Whsc2)
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Protein Structure
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Function |
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Expressed in brain, heart, spleen, lung, liver, muscle, kidney and testis. Already expressed in 7 dpc embryos. {ECO:0000269PubMed:10409432}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
12 [view]
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|
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0034244
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negative regulation of transcription elongation from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
MGI:1346098
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BG30
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PhosphoSite |
PhosphoSite-Q8BG30
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
24116
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UniGene |
Mm.423376
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RefSeq |
NP_036044
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MGI ID |
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MGI Symbol |
Nelfa
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OMIM |
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CCDS |
CCDS19208
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HPRD |
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IMGT |
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EMBL |
AF101435
AK012673
AK078760
AK088384
BC018423
BC038003
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GenPept |
AAC72983
AAH18423
AAH38003
BAB28399
BAC37379
BAC40319
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