InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: F9

Summary

InnateDB Protein

IDBP-148027.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

coagulation factor IX

Synonyms

AW111646; Cf-9; Cf9;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033477

InnateDB Gene

IDBG-148025 (F9)

Protein Structure

UniProt Annotation

Function

Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Synthesized primarily in the liver and secreted in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008233	peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

MGI:88384

InterPro

IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
IPR000742 Epidermal growth factor-like domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR001881 EGF-like calcium-binding domain
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z

PFAM

PF00594
PF00008
PF00089
PF07645

PRINTS

PR00001
PR00722

PIRSF

PIRSF001143

SMART

SM00069
SM00181
SM00020
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References