InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il17a

Summary

InnateDB Protein

IDBP-136577.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il17a

Protein Name

interleukin 17A

Synonyms

Ctla-8; Ctla8; IL-17; IL-17A; Il17;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027061

InnateDB Gene

IDBG-136575 (Il17a)

Protein Structure

UniProt Annotation

Function

Induces stromal cells to produce proinflammatory and hematopoietic cytokines. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Restricted to a subset of activated T-cells. {ECO:0000269PubMed:16990136}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	6 [view]
Protein-DNA	18 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity

Biological Process

GO:0006954	inflammatory response
GO:0032747	positive regulation of interleukin-23 production
GO:0045087	innate immune response (InnateDB)
GO:0045672	positive regulation of osteoclast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071347	cellular response to interleukin-1
GO:0072537	fibroblast activation
GO:1900017	positive regulation of cytokine production involved in inflammatory response