InnateDB Protein
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IDBP-136577.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Il17a
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Protein Name
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interleukin 17A
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Synonyms
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Ctla-8; Ctla8; IL-17; IL-17A; Il17;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000027061
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InnateDB Gene
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IDBG-136575 (Il17a)
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Protein Structure
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|
Function |
Induces stromal cells to produce proinflammatory and hematopoietic cytokines. {ECO:0000250}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Restricted to a subset of activated T-cells. {ECO:0000269PubMed:16990136}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
24
[view]
|
Protein-Protein |
6
[view]
|
Protein-DNA |
18
[view]
|
Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
|
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Predicted by orthology |
Total |
7 [view]
|
|
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Molecular Function |
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Biological Process |
GO:0006954
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inflammatory response
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GO:0032747
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positive regulation of interleukin-23 production
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GO:0045087
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innate immune response (InnateDB)
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GO:0045672
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positive regulation of osteoclast differentiation
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0071347
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cellular response to interleukin-1
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GO:0072537
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fibroblast activation
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GO:1900017
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positive regulation of cytokine production involved in inflammatory response
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Cellular Component |
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PDB ID |
MGI:107364
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InterPro |
IPR010345
Interleukin-17 family
IPR020440
Interleukin-17, chordata
IPR029034
Cystine-knot cytokine
|
PFAM |
PF06083
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PRINTS |
PR01932
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PIRSF |
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SMART |
|
TIGRFAMs |
|
Modification |
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SwissProt |
Q62386
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q544E6
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UniProt Splice Variant |
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Entrez Gene |
16171
|
UniGene |
Mm.5419
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RefSeq |
NP_034682
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MGI ID |
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MGI Symbol |
Il17a
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OMIM |
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CCDS |
CCDS14842
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HPRD |
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IMGT |
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EMBL |
AK040420
BC119303
BC119309
CH466536
U35108
U43088
|
GenPept |
AAA93253
AAB05222
AAI19304
AAI19310
BAC30590
EDL14378
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