Version 5.4
Homo sapiens Protein: PKDREJ
Summary
InnateDB Protein IDBP-11890.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKDREJ
Protein Name polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000253255
InnateDB Gene IDBG-11888 (PKDREJ)
Protein Structure
UniProt Annotation
Function May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Exclusively expressed in testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0007218 neuropeptide signaling pathway
GO:0007340 acrosome reaction
GO:0050982 detection of mechanical stimulus
GO:0055085 transmembrane transport
GO:0060046 regulation of acrosome reaction
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000203 GPS motif
IPR001024 PLAT/LH2 domain
IPR002859 PKD/REJ-like protein
IPR003915 Polycystic kidney disease type 2 protein
IPR005821 Ion transport domain
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014010 Egg jelly receptor, REJ-like
PFAM PF01825
PF01477
PF02010
PF00520
PF08016
PRINTS PR01433
PIRSF
SMART SM00303
SM00308
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NTG1
PhosphoSite PhosphoSite-Q9NTG1
TrEMBL A6MW40
UniProt Splice Variant
Entrez Gene 10343
UniGene Hs.609094
RefSeq NP_006062
HUGO HGNC:9015
OMIM 604670
CCDS CCDS14073
HPRD 05239
IMGT
EMBL AF116458 AL031034 AL078611 AL137288 CH471138 EF517278 Z93024
GenPept AAD18021 ABR22603 CAB70680 CAI18792 CAI18795 EAW73411

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca