Homo sapiens Gene: IL1A | |||||||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-66482.6 | ||||||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||
Gene Symbol | IL1A | ||||||||||||||||||||||||||||||||||||||||
Gene Name | interleukin 1, alpha | ||||||||||||||||||||||||||||||||||||||||
Synonyms | IL-1A; IL1; IL1-ALPHA; IL1F1 | ||||||||||||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000115008 | ||||||||||||||||||||||||||||||||||||||||
Encoded Proteins |
interleukin 1, alpha
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Protein Structure | |||||||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||||||||||||||
Summary |
Interleukin-1 (IL1A/IL1B) plays a key role in the interaction between local vessel wall cells and invading monocytes to multiply cholesterol-triggered inflammation in the vessel wall.
IFNG interferes with the IL-1/NFKBIZ axis in β-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFNG and IL22, and diminished production of IL17A.
CASP4 is a critical regulator of noncanonical inflammasome activation that initiates defence against bacterial pathogens in primary macrophages by mediating cell death and IL1A release
IL1A directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||||
Summary |
[Mus musculus] Under acidic conditions both pro-inflammatory forms of Il1a and Il1b are regulated independently of the NLRP3 inflammasome.
[Mus musculus] In response to adenovirus infection, the IL1A-IL1R1-CXCR2 signalling axis cooperates with complement to recruit Ly-6G+7/4+ polymorphonuclear leukocytes to the splenic marginal zone (MZ) in the proximity of virus-containing MARCO+ residential MZ macrophages, which are subsequently eliminated.
[Mus musculus] NLRP3 inflammasome formation is dispensable for alum-induced innate immunity but Il1a and Il1b are both necessary for alum-induced neutrophil influx in vivo.
[Mus musculus] Il1a directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
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Entrez Gene | |||||||||||||||||||||||||||||||||||||||||
Summary |
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008] The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer\'s disease. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 2:112773915-112784590 | ||||||||||||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||||
Band | q14.1 | ||||||||||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||||||||||
NETPATH |
IL1 pathway
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REACTOME |
Interleukin-1 signaling pathway
Interleukin-1 processing pathway
Cellular responses to stress pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Cellular Senescence pathway
Signaling by Interleukins pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
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KEGG |
Hematopoietic cell lineage pathway
Apoptosis pathway
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Type I diabetes mellitus pathway
Graft-versus-host disease pathway
Prion diseases pathway
Leishmaniasis pathway
Osteoclast differentiation pathway
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INOH |
IL-1 signaling pathway pathway
JAK STAT pathway and regulation pathway
GPCR signaling pathway
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PID NCI |
IL1-mediated signaling events
a6b1 and a6b4 Integrin signaling
Validated transcriptional targets of deltaNp63 isoforms
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Cross-References | |||||||||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||||||||
UniGene | Hs.1722 | ||||||||||||||||||||||||||||||||||||||||
RefSeq | NM_000575 | ||||||||||||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||||||
CCDS | CCDS2101 | ||||||||||||||||||||||||||||||||||||||||
HPRD | 00988 | ||||||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||||||