InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL1A

Summary

InnateDB Gene

IDBG-66482.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL1A

Gene Name

interleukin 1, alpha

Synonyms

IL-1A; IL1; IL1-ALPHA; IL1F1

Species

Homo sapiens

Ensembl Gene

ENSG00000115008

Encoded Proteins

IDBP-66484

interleukin 1, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25463072

Interleukin-1 (IL1A/IL1B) plays a key role in the interaction between local vessel wall cells and invading monocytes to multiply cholesterol-triggered inflammation in the vessel wall.

PMID 25474109

IFNG interferes with the IL-1/NFKBIZ axis in β-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFNG and IL22, and diminished production of IL17A.

PMID 25964352

CASP4 is a critical regulator of noncanonical inflammasome activation that initiates defence against bacterial pathogens in primary macrophages by mediating cell death and IL1A release

PMID 26439902

IL1A directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.

InnateDB Annotation from Orthologs

Summary

PMID 24022484

[Mus musculus] Under acidic conditions both pro-inflammatory forms of Il1a and Il1b are regulated independently of the NLRP3 inflammasome.

PMID 24651866

[Mus musculus] In response to adenovirus infection, the IL1A-IL1R1-CXCR2 signalling axis cooperates with complement to recruit Ly-6G+7/4+ polymorphonuclear leukocytes to the splenic marginal zone (MZ) in the proximity of virus-containing MARCO+ residential MZ macrophages, which are subsequently eliminated.

PMID 26536497

[Mus musculus] NLRP3 inflammasome formation is dispensable for alum-induced innate immunity but Il1a and Il1b are both necessary for alum-induced neutrophil influx in vivo.

PMID 26439902

[Mus musculus] Il1a directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.

Entrez Gene

Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer\'s disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:112773915-112784590

Strand

Reverse strand

Band

q14.1

Transcripts

ENST00000263339

ENSP00000263339

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	9 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005149	interleukin-1 receptor binding
GO:0005507	copper ion binding
GO:0005515	protein binding

Biological Process

GO:0001660	fever generation
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0019221	cytokine-mediated signaling pathway
GO:0034605	cellular response to heat
GO:0035234	ectopic germ cell programmed cell death
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046688	response to copper ion
GO:0050715	positive regulation of cytokine secretion
GO:0051781	positive regulation of cell division
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand