Homo sapiens Gene: IL29
Summary
InnateDB Gene IDBG-50119.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL29
Gene Name interleukin 29 (interferon, lambda 1)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182393
Encoded Proteins
interleukin 29 (interferon, lambda 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL29 is able to efficiently inhibit Herpes Simplex Virus Type-1 replication in neuronal cells by inducing the expression of TLR as well as activate the TLR-mediated interferon antiviral pathway.
IFNL1 (IL29), IFNL2 and IFNL3 have different effects on Toll-like receptor-related gene expression in HepG2 cells.
IFN-λ1 is able to augment TLR-mediated B cell activation, partially attributed to an upregulation of TLR7 expression
Influenza B virus induces IRF3 activation and IL29 (IFNL1) gene expression without a requirement for viral protein synthesis or replication and DDX58 is the critical pattern recognition receptor needed for IRF3 activation.
Entrez Gene
Summary This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:39296325-39298673
Strand Forward strand
Band q13.2
Transcripts
ENST00000333625 ENSP00000329991
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 0
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0032003 interleukin-28 receptor binding
Biological Process
GO:0002829 negative regulation of type 2 immune response
GO:0007259 JAK-STAT cascade
GO:0008285 negative regulation of cell proliferation
GO:0032696 negative regulation of interleukin-13 production
GO:0032714 negative regulation of interleukin-5 production
GO:0032729 positive regulation of interferon-gamma production
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043381 negative regulation of memory T cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045345 positive regulation of MHC class I biosynthetic process
GO:0045581 negative regulation of T cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046427 positive regulation of JAK-STAT cascade
GO:0050778 positive regulation of immune response
GO:0051607 defense response to virus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0032002 interleukin-28 receptor complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q8IU54
TrEMBL E2JF13
UniProt Splice Variant
Entrez Gene 282618
UniGene Hs.406745
RefSeq NM_172140
HUGO HGNC:18363
OMIM 607403
CCDS CCDS12531
HPRD
IMGT
EMBL AC011445 AY129150 AY184372 AY336716 BC074985 BC117482 BC126183 HQ214053
GenPept AAH74985 AAI17483 AAI26184 AAN28265 AAN86125 AAR24511 ADO12077
RNA Seq Atlas 282618