InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL29

Summary

InnateDB Gene

IDBG-50119.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL29

Gene Name

interleukin 29 (interferon, lambda 1)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000182393

Encoded Proteins

IDBP-50121

interleukin 29 (interferon, lambda 1)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21499846

IL29 is able to efficiently inhibit Herpes Simplex Virus Type-1 replication in neuronal cells by inducing the expression of TLR as well as activate the TLR-mediated interferon antiviral pathway.

PMID 24041672

IFNL1 (IL29), IFNL2 and IFNL3 have different effects on Toll-like receptor-related gene expression in HepG2 cells.

PMID 26130701

IFN-λ1 is able to augment TLR-mediated B cell activation, partially attributed to an upregulation of TLR7 expression

PMID 26378160

Influenza B virus induces IRF3 activation and IL29 (IFNL1) gene expression without a requirement for viral protein synthesis or replication and DDX58 is the critical pattern recognition receptor needed for IRF3 activation.

Entrez Gene

Summary

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:39296325-39298673

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000333625

ENSP00000329991

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	0
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0032003	interleukin-28 receptor binding

Biological Process

GO:0002829	negative regulation of type 2 immune response
GO:0007259	JAK-STAT cascade
GO:0008285	negative regulation of cell proliferation
GO:0032696	negative regulation of interleukin-13 production
GO:0032714	negative regulation of interleukin-5 production
GO:0032729	positive regulation of interferon-gamma production
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
GO:0043381	negative regulation of memory T cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045345	positive regulation of MHC class I biosynthetic process
GO:0045581	negative regulation of T cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046427	positive regulation of JAK-STAT cascade
GO:0050778	positive regulation of immune response
GO:0051607	defense response to virus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0032002	interleukin-28 receptor complex

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

Q8IU54

TrEMBL

E2JF13

UniProt Splice Variant

Entrez Gene

282618

UniGene

Hs.406745

RefSeq

NM_172140

HUGO

HGNC:18363

OMIM

607403

CCDS

CCDS12531

HPRD

IMGT

EMBL

AC011445 AY129150 AY184372 AY336716 BC074985 BC117482 BC126183 HQ214053

GenPept

AAH74985 AAI17483 AAI26184 AAN28265 AAN86125 AAR24511 ADO12077

RNA Seq Atlas

282618