InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: P2rx7

Summary

InnateDB Gene

IDBG-198410.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2rx7

Gene Name

purinergic receptor P2X, ligand-gated ion channel, 7

Synonyms

AI467586; P2X(7); P2X7R

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029468

Encoded Proteins

IDBP-198412

purinergic receptor P2X, ligand-gated ion channel, 7

IDBP-198414

purinergic receptor P2X, ligand-gated ion channel, 7

IDBP-198416

purinergic receptor P2X, ligand-gated ion channel, 7

IDBP-400271

purinergic receptor P2X, ligand-gated ion channel, 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21988719

P2rx7 activation in lipopolysaccharide (LPS)-primed myeloid cells results in secretion of pro-inflammatory cytokines Il1b and Il18. In addition, P2rx7 functions in the recognition and phagocytosis of non-opsonized bacteria and apoptotic cells. (Demonstrated in human)

InnateDB Annotation from Orthologs

Summary

PMID 18765670

[Homo sapiens] P2X7 activity is modulated by human cathelicidin CAMP (LL-37) receptor in a structure-dependent manner and is involved in the proliferative cell response to CAMP.

PMID 21988719

[Homo sapiens] P2RX7 activation in lipopolysaccharide (LPS)-primed myeloid cells results in secretion of pro-inflammatory cytokines IL1B and IL18. In addition, P2RX7 functions in the recognition and phagocytosis of non-opsonized bacteria and apoptotic cells.

PMID 23479230

[Homo sapiens] P2RX7 engagement with ATP analog initiates cutaneous inflammation, dendritic cell differentiation, and induction of Th17 immunity.

PMID 25651887

[Homo sapiens] Stimulation of P2RX7 receptors activates ANO6 to enhance bacterial phagocytosis and killing by macrophages.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089041:
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:122643911-122691432

Strand

Forward strand

Band

Transcripts

ENSMUST00000031425	ENSMUSP00000031425
ENSMUST00000086247	ENSMUSP00000083425
ENSMUST00000100737	ENSMUSP00000098303
ENSMUST00000121489	ENSMUSP00000112440

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0001530	lipopolysaccharide binding
GO:0001614	purinergic nucleotide receptor activity
GO:0004872	receptor activity
GO:0004931	extracellular ATP-gated cation channel activity
GO:0005102	receptor binding
GO:0005216	ion channel activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0015267	channel activity
GO:0097110	scaffold protein binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0000902	cell morphogenesis
GO:0001845	phagolysosome assembly
GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0001934	positive regulation of protein phosphorylation
GO:0002028	regulation of sodium ion transport
GO:0006468	protein phosphorylation
GO:0006509	membrane protein ectodomain proteolysis
GO:0006649	phospholipid transfer to membrane
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006884	cell volume homeostasis
GO:0006900	membrane budding
GO:0006954	inflammatory response
GO:0007005	mitochondrion organization
GO:0007009	plasma membrane organization
GO:0007166	cell surface receptor signaling pathway
GO:0009612	response to mechanical stimulus
GO:0009617	response to bacterium
GO:0010033	response to organic substance
GO:0010043	response to zinc ion
GO:0010467	gene expression
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0012501	programmed cell death
GO:0014049	positive regulation of glutamate secretion
GO:0014054	positive regulation of gamma-aminobutyric acid secretion
GO:0014070	response to organic cyclic compound
GO:0016079	synaptic vesicle exocytosis
GO:0016485	protein processing
GO:0019228	neuronal action potential
GO:0019233	sensory perception of pain
GO:0019835	cytolysis
GO:0030501	positive regulation of bone mineralization
GO:0031668	cellular response to extracellular stimulus
GO:0032060	bleb assembly
GO:0032308	positive regulation of prostaglandin secretion
GO:0032496	response to lipopolysaccharide
GO:0032731	positive regulation of interleukin-1 beta production
GO:0032755	positive regulation of interleukin-6 production
GO:0032963	collagen metabolic process
GO:0033198	response to ATP
GO:0034220	ion transmembrane transport
GO:0034405	response to fluid shear stress
GO:0035590	purinergic nucleotide receptor signaling pathway
GO:0042098	T cell proliferation
GO:0042493	response to drug
GO:0043029	T cell homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0043132	NAD transport
GO:0043409	negative regulation of MAPK cascade
GO:0043410	positive regulation of MAPK cascade
GO:0044254	multicellular organismal protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045332	phospholipid translocation
GO:0045778	positive regulation of ossification
GO:0045779	negative regulation of bone resorption
GO:0045919	positive regulation of cytolysis
GO:0046513	ceramide biosynthetic process
GO:0046931	pore complex assembly
GO:0048705	skeletal system morphogenesis
GO:0048873	homeostasis of number of cells within a tissue
GO:0050714	positive regulation of protein secretion
GO:0050715	positive regulation of cytokine secretion
GO:0050717	positive regulation of interleukin-1 alpha secretion
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0050830	defense response to Gram-positive bacterium
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051259	protein oligomerization
GO:0051495	positive regulation of cytoskeleton organization
GO:0051592	response to calcium ion
GO:0051602	response to electrical stimulus
GO:0051899	membrane depolarization
GO:0051901	positive regulation of mitochondrial depolarization
GO:0055085	transmembrane transport
GO:0070230	positive regulation of lymphocyte apoptotic process
GO:0072593	reactive oxygen species metabolic process
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0005639	integral component of nuclear inner membrane
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0031594	neuromuscular junction
GO:0032059	bleb
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0045202	synapse