Version 5.4
Homo sapiens Gene: PLAT
Summary
InnateDB Gene IDBG-19829.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLAT
Gene Name plasminogen activator, tissue
Synonyms T-PA; TPA
Species Homo sapiens
Ensembl Gene ENSG00000104368
Encoded Proteins
IDBP-19831
plasminogen activator, tissue
IDBP-19833
plasminogen activator, tissue
IDBP-369275
plasminogen activator, tissue
IDBP-369276
plasminogen activator, tissue
IDBP-473865
plasminogen activator, tissue
IDBP-478527
plasminogen activator, tissue
IDBP-475910
plasminogen activator, tissue
IDBP-483323
plasminogen activator, tissue
IDBP-477738
plasminogen activator, tissue
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:42175233-42207724
Strand Reverse strand
Band p11.21
Transcripts
ENST00000220809 ENSP00000220809
ENST00000352041 ENSP00000270188
ENST00000429089 ENSP00000392045
ENST00000429710 ENSP00000407861
ENST00000519510 ENSP00000428886
ENST00000524009 ENSP00000429401
ENST00000522812
ENST00000521042 ENSP00000429542
ENST00000524261
ENST00000521647
ENST00000520523 ENSP00000428797
ENST00000521694 ENSP00000429801
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0006464 cellular protein modification process
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0014909 smooth muscle cell migration
GO:0031639 plasminogen activation
GO:0035249 synaptic transmission, glutamatergic
GO:0042060 wound healing
GO:0042730 fibrinolysis
GO:0043434 response to peptide hormone
GO:0045861 negative regulation of proteolysis
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048167 regulation of synaptic plasticity
GO:0051591 response to cAMP
GO:0060279 positive regulation of ovulation
GO:0071549 cellular response to dexamethasone stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0030141 secretory granule
GO:0045177 apical part of cell
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031538
View Gene Order
ENSBTAG00000001244
Not yet available
Pathways
NETPATH
REACTOME
REACT_641
Dissolution of Fibrin Clot pathway
REACT_16888
Signaling by PDGF pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111102
Signal Transduction pathway
REACT_267716
Orphan transporters pathway
REACT_604
Hemostasis pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
INOH
PID NCI
integrin2_pathway
Beta2 integrin cell surface interactions
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.491582
RefSeq NM_000930 NM_033011
HUGO
OMIM
CCDS CCDS6126 CCDS6127
HPRD 01419
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca