InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Chd3

Summary

InnateDB Gene

IDBG-190457.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chd3

Gene Name

chromodomain helicase DNA binding protein 3

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018474

Encoded Proteins

IDBP-190461

chromodomain helicase DNA binding protein 3

IDBP-264062

chromodomain helicase DNA binding protein 3

IDBP-532337

chromodomain helicase DNA binding protein 3

IDBP-538626

chromodomain helicase DNA binding protein 3

IDBP-533920

chromodomain helicase DNA binding protein 3

IDBP-532863

chromodomain helicase DNA binding protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170004:
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:69343273-69369406

Strand

Reverse strand

Band

Transcripts

ENSMUST00000092971	ENSMUSP00000090649
ENSMUST00000108661	ENSMUSP00000104301
ENSMUST00000122992
ENSMUST00000135909
ENSMUST00000128981	ENSMUSP00000122137
ENSMUST00000146930
ENSMUST00000144332
ENSMUST00000151436	ENSMUSP00000118172
ENSMUST00000154046	ENSMUSP00000121192
ENSMUST00000144701	ENSMUSP00000114520

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 121 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	121 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006333	chromatin assembly or disassembly
GO:0006355	regulation of transcription, DNA-templated
GO:0007051	spindle organization
GO:0051297	centrosome organization