Mus musculus Gene: Ap3b1 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-173348.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | Ap3b1 | ||||||||||||||||||||||||
Gene Name | adaptor-related protein complex 3, beta 1 subunit | ||||||||||||||||||||||||
Synonyms | AP-3; AU015684; beta3A; C78395; Hps2; pe; pearl; rim2 | ||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000021686 | ||||||||||||||||||||||||
Encoded Proteins |
adaptor-related protein complex 3, beta 1 subunit
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||
Summary |
Ap3b1 (AP-3), a lysosome-related organelle trafficking and biogenesis protein, is required for the production of pro-inflammatory cytokines in plasmacytoid dendritic cells upon recognition of viral nucleic acids by endosomal Tlr7 or Tlr9.
Ap3b1 is crucial for the trafficking of Tlr9 to specific endosomal compartments for the induction of type I interferon.
Cytokine activation as a result of Tlr2 stimulation is mediated by the phagosomal trafficking molecule Ap3b1 (AP-3).
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||
Summary |
[Homo sapiens] AP3B1 (AP-3), a lysosome-related organelle trafficking and biogenesis protein, is required for the production of pro-inflammatory cytokines in plasmacytoid dendritic cells upon recognition of viral nucleic acids by endosomal TLR7 or TLR9.
[Homo sapiens] AP3B1 is crucial for the trafficking of TLR9 to specific endosomal compartments for the induction of type I interferon.
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Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132842:
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 13:94358960-94566316 | ||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||
Band | C3 | ||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME |
Membrane Trafficking pathway
Golgi Associated Vesicle Biogenesis pathway
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
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KEGG |
Lysosome pathway
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INOH | |||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME |
Golgi Associated Vesicle Biogenesis pathway
Clathrin derived vesicle budding pathway
trans-Golgi Network Vesicle Budding pathway
Membrane Trafficking pathway
Golgi Associated Vesicle Biogenesis pathway
Clathrin derived vesicle budding pathway
trans-Golgi Network Vesicle Budding pathway
Membrane Trafficking pathway
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KEGG |
Lysosome pathway
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INOH | |||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||
SwissProt | Q9Z1T1 | ||||||||||||||||||||||||
TrEMBL | Q3UPG0 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 11774 | ||||||||||||||||||||||||
UniGene | Mm.21185 | ||||||||||||||||||||||||
RefSeq | NM_009680 | ||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | CCDS26693 | ||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
MGI ID | MGI:1333879 | ||||||||||||||||||||||||
MGI Symbol | Ap3b1 | ||||||||||||||||||||||||
EMBL | AC122373 AC123043 AF103809 AF255566 AF255567 AF255568 AF255569 AF255570 AF255571 AF255572 AF255573 AF255574 AF255575 AF255576 AF255577 AF255578 AF255579 AF255580 AF255581 AF255582 AF255583 AF255584 AF255585 AF255586 AF255587 AF255588 AF255589 AK143559 BC015068 | ||||||||||||||||||||||||
GenPept | AAC78338 AAG23622 AAH15068 BAE25435 | ||||||||||||||||||||||||
RNA Seq Atlas | 11774 | ||||||||||||||||||||||||