Version 5.4
| Mus musculus Gene: Ifnb1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-162198.6 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Symbol | Ifnb1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Name | interferon beta 1, fibroblast | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms | Ifb; IFN-beta; IFNB | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000048806 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
interferon beta 1, fibroblast
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
Ifnb1 deficiency results in a partial suppression of the sterol pathway in macrophages during viral infections, thereby linking the regulation of lipid metabolism pathway with interferon anti-viral defence responses.
Ifnb1 secretion is greater upon viable E. coli infection in comparison to heat killed E. coli vaccine or LPS. The induction of Ifnb1 is dependent on Ticam1-Irf3 signalling.
Ifnb1 expression pattern during viral infection is a highly stochastic process influenced by cell-to-cell variability in viral induction processes.
Ifnb1 production is fundamental to the efficient control of Listeria monocytogenes during the early innate phase of infection. NK cells treated with Ifnb1 during early infection were able to reduce bacterial titer in the spleen and significantly improve survival of infected mice.
The noncanonical NFκB pathway regulates histone modifications at the Ifnb1 promoter resulting in attenuated recruitment of Rela and histone demethylase, Kdm4a, to the Ifnb1 promoter. This provides a mechanism for regulating the induction of type I interferons .
The innate immune system plays a role in immunogenic tumour recognition. Tumor-cell-derived DNA triggers Ifnb1 production and dendritic cell activation via Tmem173 and Irf3 cytosolic DNA sensing pathways.
Ifnb1 selectively restricts the transcriptional responses mediated by both the TLRs and the NOD-like receptors in Salmonella enterica serovar Typhimurium infection in macrophages.
Atf3 plays an important role in modulating IFN responses in macrophages by controlling basal and inducible levels of Ifnb1, as well as the expression of genes downstream of IFN signalling.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] IFNB1 has an essential role in the anti-viral response and optineurin (OPTN) has a role in the inhibition of virus-triggered IFNB1 induction.
[Homo sapiens] Viral RNA-induced IFNB1 production is suppressed by oncogenic RAS through negative regulation of RIG-I signalling, leading to promotion of virus spread.
[Homo sapiens] IFNB1 expression is inhibited by influenza A virus polymerase by binding to IFN-beta promoter stimulator 1 (MAVS).
[Homo sapiens] IFNB1 is a type I interferon (IFN-I) and the IFN-I family comprises a wide number of cytokines with different modulatory effects on angiogenesis, cell growth, fibrosis, apoptosis and autoimmunity.
[Homo sapiens] IFNB1 deficiency results in a partial suppression of the sterol pathway in macrophages during viral infections, thereby linking the regulation of lipid metabolism pathway with interferon anti-viral defence responses. (Demonstrated in murine model)
[Homo sapiens] IFNB1 secretion is greater upon viable E. coli infection in comparison to heat killed E. coli vaccine or LPS. The induction of IFNB1 is dependent on TICAM1-IRF3 signalling. (Demonstrated in murine model).
[Homo sapiens] IFNB1 expression pattern during viral infection is a highly stochastic process influenced by cell-to-cell variability in viral induction processes. (Demonstrated in mice)
[Homo sapiens] IFNB1 production is fundamental to the efficient control of Listeria monocytogenes during the early innate phase of infection. NK cells treated with IFNB1 during early infection were able to reduce bacterial titer in the spleen and significantly improve survival of infected mice. (Demonstrated in mouse)
[Homo sapiens] Macrocyclic NS3-4A resistance-associated amino acid variants (RAVs) with substitutions at residue D168 of the hepatitis C virus protease result in an increased capacity of NS3-4A to cleave MAVS and suppress IFNB1 induction.
[Homo sapiens] Coronavirus engages papain-like proteases to escape from the innate antiviral response of the host by inhibiting TP53-IRF7-IFNB1 signalling.
[Homo sapiens] Hepatitis B virus (HBV) polymerase inhibits TMEM173-stimulated IRF3 activation and IFNB1 induction.
[Homo sapiens] ELAVL1 is required for the stabilization of IFNB1 mRNA, and suppression of ELAVL1 leads to impaired expression of IFNB1 in response to poly(I:C) treatment.
[Homo sapiens] IFNB1 selectively restricts the transcriptional responses mediated by both the TLRs and the NOD-like receptors in Salmonella enterica serovar Typhimurium infection in macrophages.
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| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171855:
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| Gene Information | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 4:88522025-88522774 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Band | C4 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| REACTOME |
Innate Immune System pathway
Hemostasis pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
TRAF6 mediated IRF7 activation pathway
Factors involved in megakaryocyte development and platelet production pathway
Interferon Signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Regulation of IFNA signaling pathway
Interferon alpha/beta signaling pathway
TRAF3-dependent IRF activation pathway pathway
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| KEGG |
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Toll-like receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Osteoclast differentiation pathway
Hepatitis C pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH |
JAK STAT pathway and regulation pathway
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| REACTOME |
TRAF6 mediated IRF7 activation pathway
TRAF3-dependent IRF activation pathway pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Regulation of IFNA signaling pathway
Interferon alpha/beta signaling pathway
Factors involved in megakaryocyte development and platelet production pathway
Cellular responses to stress pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Interferon Signaling pathway
Immune System pathway
Cellular Senescence pathway
Oxidative Stress Induced Senescence pathway
Hemostasis pathway
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| KEGG |
Cytokine-cytokine receptor interaction pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
Hepatitis C pathway
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| INOH |
JAK STAT pathway and regulation pathway
GPCR signaling pathway
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| PID NCI |
Regulation of nuclear SMAD2/3 signaling
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| Cross-References | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| SwissProt | P01575 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| TrEMBL | Q0VE17 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | 15977 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniGene | Mm.1245 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_010510 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCDS | CCDS18318 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| MGI ID | MGI:107657 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| MGI Symbol | Ifnb1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| EMBL | BC119395 BC119397 CH466527 K00020 X14029 X14455 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| GenPept | AAA37891 AAI19396 AAI19398 CAA32190 CAA32625 EDL30977 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 15977 | ||||||||||||||||||||||||||||||||||||||||||||||||||||