Version 5.4
Homo sapiens Protein: GMFB
Summary
InnateDB Protein IDBP-7062.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GMFB
Protein Name glia maturation factor, beta
Synonyms GMF;
Species Homo sapiens
Ensembl Protein ENSP00000350757
InnateDB Gene IDBG-7060 (GMFB)
Protein Structure
UniProt Annotation
Function This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004860 protein kinase inhibitor activity
GO:0004871 signal transducer activity
GO:0008047 enzyme activator activity
GO:0008083 growth factor activity
GO:0071933 Arp2/3 complex binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0007612 learning
GO:0007626 locomotory behavior
GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation
GO:0043085 positive regulation of catalytic activity
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro IPR002108 Actin-depolymerising factor homology domain
IPR011171 Glia maturation factor beta
PFAM PF00241
PRINTS
PIRSF PIRSF001788
SMART SM00102
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P60983
PhosphoSite PhosphoSite-P60983
TrEMBL
UniProt Splice Variant
Entrez Gene 2764
UniGene Hs.665452
RefSeq NP_004115
HUGO HGNC:4373
OMIM 601713
CCDS CCDS9718
HPRD
IMGT
EMBL AB001106 AK311753 CH471061 CR542113 M86492
GenPept AAA58614 BAA19232 BAG34696 CAG46910 EAW80638

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca