InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LMCD1

Summary

InnateDB Protein

IDBP-697464.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LMCD1

Protein Name

LIM and cysteine-rich domains protein 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000007149

InnateDB Gene

IDBG-644799 (LMCD1)

Protein Structure

UniProt Annotation

Function

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=May shuttle between the cytoplasm and the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010611	regulation of cardiac muscle hypertrophy
GO:0070886	positive regulation of calcineurin-NFAT signaling cascade

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR001781 Zinc finger, LIM-type
IPR010442 PET domain

PFAM

PF00412
PF06297

PRINTS

PIRSF

SMART

SM00132

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q17QE2

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

540474

UniGene

Bt.43510

RefSeq

NP_001069690

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC118414

GenPept

AAI18415