InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RNF138

Summary

InnateDB Protein

IDBP-696284.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF138

Protein Name

E3 ubiquitin-protein ligase RNF138

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026851

InnateDB Gene

IDBG-643706 (RNF138)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019901	protein kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0016055	Wnt signaling pathway
GO:0016567	protein ubiquitination

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001841 Zinc finger, RING-type
IPR004181 Zinc finger, MIZ-type
IPR008598 Drought induced 19 protein-like, zinc-binding domain
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF13639
PF14634
PF02891
PF05605
PF00097

PRINTS

PIRSF

SMART

SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q32LN5