Version 5.4
Bos taurus Protein: HDAC2
Summary
InnateDB Protein IDBP-682748.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDAC2
Protein Name histone deacetylase 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000015734
InnateDB Gene IDBG-631217 (HDAC2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 387 interaction(s) predicted by orthology.
Predicted by orthology
Total 387 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016787 hydrolase activity
GO:0019213 deacetylase activity
GO:0019899 enzyme binding
GO:0031078 histone deacetylase activity (H3-K14 specific)
GO:0031490 chromatin DNA binding
GO:0031492 nucleosomal DNA binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032129 histone deacetylase activity (H3-K9 specific)
GO:0033558 protein deacetylase activity
GO:0034739 histone deacetylase activity (H4-K16 specific)
GO:0035851 Krueppel-associated box domain binding
GO:0043565 sequence-specific DNA binding
GO:0044822 poly(A) RNA binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006344 maintenance of chromatin silencing
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006476 protein deacetylation
GO:0008284 positive regulation of cell proliferation
GO:0009913 epidermal cell differentiation
GO:0010870 positive regulation of receptor biosynthetic process
GO:0010977 negative regulation of neuron projection development
GO:0016358 dendrite development
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0021766 hippocampus development
GO:0030182 neuron differentiation
GO:0032922 circadian regulation of gene expression
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0043044 ATP-dependent chromatin remodeling
GO:0043066 negative regulation of apoptotic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045862 positive regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051896 regulation of protein kinase B signaling
GO:0055013 cardiac muscle cell development
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060297 regulation of sarcomere organization
GO:0060789 hair follicle placode formation
GO:0061029 eyelid development in camera-type eye
GO:0061198 fungiform papilla formation
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090311 regulation of protein deacetylation
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0000790 nuclear chromatin
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005657 replication fork
GO:0005667 transcription factor complex
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0017053 transcriptional repressor complex
GO:0035098 ESC/E(Z) complex
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR000286 Histone deacetylase superfamily
IPR003084 Histone deacetylase
IPR023801 Histone deacetylase domain
PFAM PF00850
PRINTS PR01270
PR01271
PIRSF PIRSF037913
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MFZ7
UniProt Splice Variant
Entrez Gene 407223
UniGene
RefSeq NP_001068614
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02025850 DAAA02025851
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca