InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: IDH2

Summary

InnateDB Protein

IDBP-680661.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IDH2

Protein Name

Isocitrate dehydrogenase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000018741

InnateDB Gene

IDBG-629262 (IDH2)

Protein Structure

UniProt Annotation

Function

Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004450	isocitrate dehydrogenase (NADP+) activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872	metal ion binding
GO:0051287	NAD binding

Biological Process

GO:0006097	glyoxylate cycle
GO:0006099	tricarboxylic acid cycle
GO:0006102	isocitrate metabolic process
GO:0006103	2-oxoglutarate metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane

Protein Structure and Domains

PDB ID

InterPro

IPR004790 Isocitrate dehydrogenase NADP-dependent
IPR024084 Isopropylmalate dehydrogenase-like domain

PFAM

PF00180

PRINTS

PIRSF

PIRSF000108

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q04467

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

327669

UniGene

Bt.5520

RefSeq

NP_786984

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102509 X69432

GenPept

AAI02510 CAA49207