InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: E2F1

Summary

InnateDB Protein

IDBP-67218.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2F1

Protein Name

E2F transcription factor 1

Synonyms

E2F-1; RBAP1; RBBP3; RBP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000345571

InnateDB Gene

IDBG-67214 (E2F1)

Protein Structure

UniProt Annotation

Function

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. {ECO:0000269PubMed:10675335, ECO:0000269PubMed:12717439, ECO:0000269PubMed:17704056, ECO:0000269PubMed:8170954}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 599 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	601 [view]
Protein-Protein	176 [view]
Protein-DNA	422 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000080	mitotic G1 phase
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000085	mitotic G2 phase
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0007219	Notch signaling pathway
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010628	positive regulation of gene expression
GO:0030900	forebrain development
GO:0043276	anoikis
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0048255	mRNA stabilization
GO:0051726	regulation of cell cycle
GO:0071398	cellular response to fatty acid
GO:0071456	cellular response to hypoxia
GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1990086	lens fiber cell apoptotic process
GO:2000045	regulation of G1/S transition of mitotic cell cycle