Version 5.4
Mus musculus Protein: Nup50
Summary
InnateDB Protein IDBP-624037.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nup50
Protein Name nucleoporin 50
Synonyms 1700030K07Rik; AI413123; Npap60;
Species Mus musculus
Ensembl Protein ENSMUSP00000131457
InnateDB Gene IDBG-170060 (Nup50)
Protein Structure
UniProt Annotation
Function Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin- alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B. {ECO:0000269PubMed:16222336}.
Subcellular Localization Nucleus, nuclear pore complex. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Nucleoplasmic side {ECO:0000250}. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex. Dissociates from the NPC structure early during prophase of mitosis. Associates to the newly formed nuclear membrane during telophase (By similarity). {ECO:0000250}.
Disease Associations Note=Defects in Nup50 are the cause of neural tube defects, exencephaly and intrauterine growth retardation.
Tissue Specificity Widely expressed at low levels. Highest in the developing neural tube and adult testes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0015031 protein transport
GO:0046907 intracellular transport
GO:0051028 mRNA transport
Cellular Component
GO:0005643 nuclear pore
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID MGI:1351502
InterPro IPR000156 Ran binding domain
IPR015007 Nuclear pore complex, NUP2/50/61
PFAM PF00638
PF08911
PRINTS
PIRSF
SMART SM00160
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JIH2
PhosphoSite PhosphoSite-Q9JIH2
TrEMBL
UniProt Splice Variant
Entrez Gene 18141
UniGene Mm.457709
RefSeq NP_057923
MGI ID 2C1M
MGI Symbol Nup50
OMIM
CCDS CCDS27714
HPRD
IMGT
EMBL AF229256 AF251799 AK018983 AK087706 AK133371 AK133562 AK141750 AK151947 AK152309 AK161713 AK165581 AK168888 BC059239 BC060234 BC065102 CH466550
GenPept AAF34721 AAF70057 AAH59239 AAH60234 AAH65102 BAB31500 BAC39975 BAE21620 BAE21727 BAE24822 BAE30821 BAE31115 BAE36546 BAE38272 BAE40705 EDL04446

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca