InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ube2i

Summary

InnateDB Protein

IDBP-623672.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2i

Protein Name

ubiquitin-conjugating enzyme E2I

Synonyms

5830467E05Rik; F830028O17Rik; UBC9; Ubce2i; Ubce9;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000134350

InnateDB Gene

IDBG-151396 (Ube2i)

Protein Structure

UniProt Annotation

Function

Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Essential for nuclear architecture, chromosome segregation and embryonic viability. Necessary for sumoylation of FOXL2 and KAT5 (By similarity). Sumoylates p53/TP53 at 'Lys-386'. {ECO:0000250, ECO:0000269PubMed:16326389, ECO:0000269PubMed:17187077, ECO:0000269PubMed:22214662}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body.

Disease Associations

Tissue Specificity

Present in spleen, kidney, lung, brain, heart and testis (at protein level). {ECO:0000269PubMed:9409784}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 280 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	280 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016881	acid-amino acid ligase activity
GO:0019789	SUMO ligase activity
GO:0019899	enzyme binding
GO:0043398	HLH domain binding
GO:0043425	bHLH transcription factor binding
GO:0071535	RING-like zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006464	cellular protein modification process
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007275	multicellular organismal development
GO:0010469	regulation of receptor activity
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0016925	protein sumoylation
GO:0033145	positive regulation of intracellular steroid hormone receptor signaling pathway
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity