InnateDB Protein
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IDBP-59064.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PELI3
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Protein Name
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pellino homolog 3 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000309848
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InnateDB Gene
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IDBG-59060 (PELI3)
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Protein Structure
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Function |
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. {ECO:0000269PubMed:12874243, ECO:0000269PubMed:17675297}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Highly expressed in brain, heart and testis, and at lower level in kidney, liver, lung, placenta, small intestine, spleen and stomach. Isoform 1 is not expressed in lung. {ECO:0000269PubMed:12874243}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0008063
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Toll signaling pathway
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GO:0010804
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negative regulation of tumor necrosis factor-mediated signaling pathway
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GO:0016567
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protein ubiquitination
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GO:0045087
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innate immune response (InnateDB)
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GO:2001237
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negative regulation of extrinsic apoptotic signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR006800
Pellino family
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PFAM |
PF04710
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PRINTS |
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PIRSF |
PIRSF038886
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N2H9
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PhosphoSite |
PhosphoSite-Q8N2H9
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TrEMBL |
H0YEM6
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UniProt Splice Variant |
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Entrez Gene |
246330
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UniGene |
Hs.656875
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RefSeq |
NP_001091980
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HUGO |
HGNC:30010
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OMIM |
609827
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CCDS |
CCDS41675
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HPRD |
17535
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IMGT |
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EMBL |
AF487456
AF487457
AK074201
AK075253
AK094060
AL834395
AP002748
BC021256
BC025723
CH471076
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GenPept |
AAH21256
AAH25723
AAO49465
AAO49466
BAB85015
BAC04275
BAC11499
CAD39057
EAW74533
EAW74534
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