Homo sapiens Protein: RUVBL1 | |||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||
InnateDB Protein | IDBP-55110.6 | ||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
Gene Symbol | RUVBL1 | ||||||||||||||||||||||||||||||
Protein Name | RuvB-like 1 (E. coli) | ||||||||||||||||||||||||||||||
Synonyms | ECP54; INO80H; NMP238; PONTIN; Pontin52; RVB1; TIH1; TIP49; TIP49A; | ||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||
Ensembl Protein | ENSP00000318297 | ||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-55108 (RUVBL1) | ||||||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||||||
Function | Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation.May be able to bind plasminogen at cell surface and enhance plasminogen activation. | ||||||||||||||||||||||||||||||
Subcellular Localization | Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm. Membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells. | ||||||||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||||||||
Tissue Specificity | Ubiquitously expressed with high expression in heart, skeletal muscle and testis. | ||||||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 207 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||||||
InterPro |
IPR003593
AAA+ ATPase domain IPR003959 ATPase, AAA-type, core IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal IPR010339 TIP49, C-terminal IPR012340 Nucleic acid-binding, OB-fold IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00004
PF07724 PF13304 PF05496 PF06068 |
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PRINTS | |||||||||||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||||||||||
SMART |
SM00382
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TIGRFAMs | |||||||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||
SwissProt | Q9Y265 | ||||||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9Y265 | ||||||||||||||||||||||||||||||
TrEMBL | J3QLR1 | ||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||
Entrez Gene | 8607 | ||||||||||||||||||||||||||||||
UniGene | Hs.619487 | ||||||||||||||||||||||||||||||
RefSeq | NP_003698 | ||||||||||||||||||||||||||||||
HUGO | HGNC:10474 | ||||||||||||||||||||||||||||||
OMIM | 603449 | ||||||||||||||||||||||||||||||
CCDS | CCDS3047 | ||||||||||||||||||||||||||||||
HPRD | 09143 | ||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||
EMBL | AB012122 AB451224 AC011311 AC069419 AF070735 AF099084 AF380343 AF380344 AJ010058 AK222563 AK222575 AK312290 AL449214 BC002993 BC012886 BT007057 DQ469310 Y18418 | ||||||||||||||||||||||||||||||
GenPept | AAC77819 AAD04427 AAH02993 AAH12886 AAM45570 AAP35706 ABF13334 BAA28169 BAD96283 BAD96295 BAG35217 BAG70038 CAA08986 CAB46271 | ||||||||||||||||||||||||||||||