Version 5.4
Homo sapiens Protein: TLR2
Summary
InnateDB Protein IDBP-41791.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLR2
Protein Name toll-like receptor 2
Synonyms CD282; TIL4;
Species Homo sapiens
Ensembl Protein ENSP00000260010
InnateDB Gene IDBG-41789 (TLR2)
Protein Structure
UniProt Annotation
Function Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
Subcellular Localization Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 50 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001875 lipopolysaccharide receptor activity
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0008329 signaling pattern recognition receptor activity
GO:0042497 triacyl lipopeptide binding
GO:0042498 diacyl lipopeptide binding
GO:0042834 peptidoglycan binding
GO:0046982 protein heterodimerization activity
GO:0070891 lipoteichoic acid binding
GO:0071723 lipopeptide binding
Biological Process
GO:0001666 response to hypoxia
GO:0001774 microglial cell activation
GO:0002224 toll-like receptor signaling pathway
GO:0002238 response to molecule of fungal origin
GO:0002687 positive regulation of leukocyte migration
GO:0002752 cell surface pattern recognition receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006691 leukotriene metabolic process
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007252 I-kappaB phosphorylation
GO:0008285 negative regulation of cell proliferation
GO:0009617 response to bacterium
GO:0009636 response to toxic substance
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032289 central nervous system myelin formation
GO:0032493 response to bacterial lipoprotein
GO:0032494 response to peptidoglycan
GO:0032496 response to lipopolysaccharide
GO:0032570 response to progesterone
GO:0032695 negative regulation of interleukin-12 production
GO:0032700 negative regulation of interleukin-17 production
GO:0032722 positive regulation of chemokine production
GO:0032728 positive regulation of interferon-beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032741 positive regulation of interleukin-18 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032868 response to insulin
GO:0034123 positive regulation of toll-like receptor signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0042495 detection of triacyl bacterial lipopeptide
GO:0042496 detection of diacyl bacterial lipopeptide
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0042892 chloramphenicol transport
GO:0044130 negative regulation of growth of symbiont in host
GO:0045087 innate immune response (InnateDB)
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046209 nitric oxide metabolic process
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050715 positive regulation of cytokine secretion
GO:0050729 positive regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0052063 induction by symbiont of defense-related host nitric oxide production
GO:0060907 positive regulation of macrophage cytokine production
GO:0070542 response to fatty acid
GO:0071221 cellular response to bacterial lipopeptide
GO:0071223 cellular response to lipoteichoic acid
GO:0071224 cellular response to peptidoglycan
GO:0071726 cellular response to diacyl bacterial lipopeptide
GO:0071727 cellular response to triacyl bacterial lipopeptide
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex
GO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex
GO:0042995 cell projection
GO:0044297 cell body
Protein Structure and Domains
PDB ID
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR017241 Toll-like receptor
PFAM PF01582
PF13676
PF01463
PF00560
PF13504
PF13855
PRINTS
PIRSF PIRSF037595
SMART SM00255
SM00082
SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60603
PhosphoSite PhosphoSite-O60603
TrEMBL K9MV98
UniProt Splice Variant
Entrez Gene 7097
UniGene Hs.623716
RefSeq NP_003255
HUGO HGNC:11848
OMIM 603028
CCDS CCDS3784
HPRD 04323
IMGT
EMBL AB445624 AF051152 AF502291 BC033756 CH471056 DQ012265 DQ012266 DQ012267 DQ012268 DQ012269 DQ012270 DQ012271 GQ228031 GQ228032 GQ228033 JQ481242 JQ481243 JQ481244 JQ481245 JQ481246 JQ481247 JQ481248 JQ481249 JQ481250 JQ481251 JQ481252 JQ481253 JQ481254 JQ481255 JQ481256 JQ481257 JQ481258 JQ481259 JQ481260 JQ481261 JQ481262 JQ481263 JQ481264 JQ481265 JQ481266 JQ481267 JQ481268 JQ481269 JQ481270 JQ481271 JQ481272 JQ481273 JQ481274 JQ481275 JQ481276 JQ481277 JQ481278 JQ481279 JQ481280 JQ481281 JQ481282 JQ481283 JQ481284 JQ481285 JQ481286 JQ481287 JQ481288 JQ481289 JQ481290 JQ481291 JQ481292 JQ481293 JQ481294 JQ481295 JQ481296 JQ481297 JQ481298 JQ481299 JQ481300 JQ481301 JQ481302 JQ481303 JQ481304 JQ481305 JQ481306 JQ481307 JQ481308 JQ481309 JQ481310 JQ481311 JQ481312 JQ481313 JQ481314 JQ481315 JQ481316 JQ481317 JQ481318 JQ481319 JQ481320 JQ481321 JQ481322 JQ481323 JQ481324 JQ481325 JQ481326 JQ481327 JQ481328 JQ481329 JQ481330 JQ481331 JQ481332 JQ481333 JQ481334 JQ481335 JQ481336 JQ481337 JQ481338 JQ481339 JQ481340 JQ481341 JQ481342 JQ481343 JQ481344 JQ481345 JQ481346 JQ481347 JQ481348 JQ481349 JQ481350 JQ481351 JQ481352 JQ481353 JQ481354 JQ481355 JQ481356 JQ481357 JQ481358 JQ481359 JQ481360 JQ481361 JQ481362 JQ481363 JQ481364 JQ481365 JQ481366 JQ481367 JQ481368 JQ481369 JQ481370 JQ481371 JQ481372 JQ481373 JQ481374 JQ481375 JQ481376 JQ481377 JQ481378 JQ481379 JQ481380 JQ481381 JQ481382 JQ481383 JQ481384 JQ481385 JQ481386 JQ481387 JQ481388 JQ481389 JQ481390 JQ481391 JQ481392 JQ481393 JQ481394 JQ481395 JQ481396 JQ481397 JQ481398 JQ481399 JQ481400 JQ481401 JQ481402 JQ481403 JQ481404 JQ481405 JQ481406 JQ481407 JQ481408 JQ481409 JQ481410 JQ481411 JQ481412 JQ481413 JQ481414 JQ481415 JQ481416 JQ481417 JQ481418 JQ481419 JQ481420 JQ481421 JQ481422 JQ481423 JQ481424 JQ481425 JQ481426 JQ481427 JQ481428 JQ481429 JQ481430 JQ481431 JQ481432 JQ481433 JQ481434 JQ481435 JQ481436 JQ481437 JQ481438 JQ481439 JQ481440 JQ481441 JQ481442 JQ481443 JQ481444 JQ481445 JQ481446 JQ481447 JQ481448 JQ481449 JQ481450 JQ481451 JQ481452 JQ481453 JQ481454 JQ481455 JQ481456 JQ481457 JQ481458 JQ481459 JQ481460 JQ481461 JQ481462 JQ481463 JQ481464 JQ481465 JQ481466 JQ481467 JQ481468 JQ481469 JQ481470 JQ481471 JQ481472 JQ481473 JQ481474 JQ481475 JQ481476 JQ481477 JQ481478 JQ481479 JQ481480 JQ481481 JQ481482 JQ481483 JQ481484 JQ481485 JQ481486 JQ481487 JQ481488 JQ481489 JQ481490 JQ481491 JQ481492 JQ481493 JQ481494 JQ481495 JQ481496 JQ481497 JQ481498 JQ481499 JQ481500 JQ481501 JQ481502 JQ481503 JQ481504 JQ481505 JQ481506 JQ481507 JQ481508 JQ481509 JQ481510 JQ481511 JQ481512 JQ481513 JQ481514 JQ481515 JQ481516 JQ481517 JQ481518 JQ481519 JQ481520 JQ481521 JQ481522 JQ481523 JQ481524 JQ481525 JQ481526 JQ481527 JQ481528 JQ481529 JQ481530 JQ481531 JQ481532 JQ481533 JQ481534 JQ481535 JQ481536 JQ481537 JQ481538 JQ481539 JQ481540 JQ481541 JQ481542 JQ481543 JQ481544 JQ481545 JQ481546 JQ481547 JQ481548 JQ481549 JQ481550 JQ481551 JQ481552 JQ481553 JQ481554 JQ481555 JQ481556 JQ481557 JQ481558 JQ481559 JQ481560 JQ481561 JQ481562 JQ481563 JQ481564 JQ481565 JQ481566 JQ481567 JQ481568 JQ481569 JQ481570 JQ481571 JQ481572 JQ481573 JQ481574 JQ481575 JQ481576 JQ481577 JQ481578 JQ481579 JQ481580 JQ481581 JQ481582 JQ481583 JQ481584 JQ481585 JQ481586 JQ481587 JQ481588 JQ481589 JQ481590 JQ481591 JQ481592 JQ481593 JQ481594 JQ481595 JQ481596 JQ481597 JQ481598 JQ481599 JQ481600 JQ481601 JQ481602 JQ481603 JQ481604 JQ481605 JQ481606 JQ481607 JQ481608 JQ481609 JQ481610 JQ481611 JQ481612 JQ481613 JQ481614 JQ481615 JQ481616 JQ481617 JQ481618 JQ481619 JQ481620 JQ481621 JQ481622 JQ481623 JQ481624 JQ481625 JQ481626 JQ481627 JQ481628 JQ481629 JQ481630 U88878
GenPept AAC34133 AAC34377 AAH33756 AAM23001 AAY85644 AAY85645 AAY85646 AAY85647 AAY85648 AAY85649 AAY85650 ACS88975 ACS88976 ACS88977 AFX72318 AFX72319 AFX72320 AFX72321 AFX72322 AFX72323 AFX72324 AFX72325 AFX72326 AFX72327 AFX72328 AFX72329 AFX72330 AFX72331 AFX72332 AFX72333 AFX72334 AFX72335 AFX72336 AFX72337 AFX72338 AFX72339 AFX72340 AFX72341 AFX72342 AFX72343 AFX72344 AFX72345 AFX72346 AFX72347 AFX72348 AFX72349 AFX72350 AFX72351 AFX72352 AFX72353 AFX72354 AFX72355 AFX72356 AFX72357 AFX72358 AFX72359 AFX72360 AFX72361 AFX72362 AFX72363 AFX72364 AFX72365 AFX72366 AFX72367 AFX72368 AFX72369 AFX72370 AFX72371 AFX72372 AFX72373 AFX72374 AFX72375 AFX72376 AFX72377 AFX72378 AFX72379 AFX72380 AFX72381 AFX72382 AFX72383 AFX72384 AFX72385 AFX72386 AFX72387 AFX72388 AFX72389 AFX72390 AFX72391 AFX72392 AFX72393 AFX72394 AFX72395 AFX72396 AFX72397 AFX72398 AFX72399 AFX72400 AFX72401 AFX72402 AFX72403 AFX72404 AFX72405 AFX72406 AFX72407 AFX72408 AFX72409 AFX72410 AFX72411 AFX72412 AFX72413 AFX72414 AFX72415 AFX72416 AFX72417 AFX72418 AFX72419 AFX72420 AFX72421 AFX72422 AFX72423 AFX72424 AFX72425 AFX72426 AFX72427 AFX72428 AFX72429 AFX72430 AFX72431 AFX72432 AFX72433 AFX72434 AFX72435 AFX72436 AFX72437 AFX72438 AFX72439 AFX72440 AFX72441 AFX72442 AFX72443 AFX72444 AFX72445 AFX72446 AFX72447 AFX72448 AFX72449 AFX72450 AFX72451 AFX72452 AFX72453 AFX72454 AFX72455 AFX72456 AFX72457 AFX72458 AFX72459 AFX72460 AFX72461 AFX72462 AFX72463 AFX72464 AFX72465 AFX72466 AFX72467 AFX72468 AFX72469 AFX72470 AFX72471 AFX72472 AFX72473 AFX72474 AFX72475 AFX72476 AFX72477 AFX72478 AFX72479 AFX72480 AFX72481 AFX72482 AFX72483 AFX72484 AFX72485 AFX72486 AFX72487 AFX72488 AFX72489 AFX72490 AFX72491 AFX72492 AFX72493 AFX72494 AFX72495 AFX72496 AFX72497 AFX72498 AFX72499 AFX72500 AFX72501 AFX72502 AFX72503 AFX72504 AFX72505 AFX72506 AFX72507 AFX72508 AFX72509 AFX72510 AFX72511 AFX72512 AFX72513 AFX72514 AFX72515 AFX72516 AFX72517 AFX72518 AFX72519 AFX72520 AFX72521 AFX72522 AFX72523 AFX72524 AFX72525 AFX72526 AFX72527 AFX72528 AFX72529 AFX72530 AFX72531 AFX72532 AFX72533 AFX72534 AFX72535 AFX72536 AFX72537 AFX72538 AFX72539 AFX72540 AFX72541 AFX72542 AFX72543 AFX72544 AFX72545 AFX72546 AFX72547 AFX72548 AFX72549 AFX72550 AFX72551 AFX72552 AFX72553 AFX72554 AFX72555 AFX72556 AFX72557 AFX72558 AFX72559 AFX72560 AFX72561 AFX72562 AFX72563 AFX72564 AFX72565 AFX72566 AFX72567 AFX72568 AFX72569 AFX72570 AFX72571 AFX72572 AFX72573 AFX72574 AFX72575 AFX72576 AFX72577 AFX72578 AFX72579 AFX72580 AFX72581 AFX72582 AFX72583 AFX72584 AFX72585 AFX72586 AFX72587 AFX72588 AFX72589 AFX72590 AFX72591 AFX72592 AFX72593 AFX72594 AFX72595 AFX72596 AFX72597 AFX72598 AFX72599 AFX72600 AFX72601 AFX72602 AFX72603 AFX72604 AFX72605 AFX72606 AFX72607 AFX72608 AFX72609 AFX72610 AFX72611 AFX72612 AFX72613 AFX72614 AFX72615 AFX72616 AFX72617 AFX72618 AFX72619 AFX72620 AFX72621 AFX72622 AFX72623 AFX72624 AFX72625 AFX72626 AFX72627 AFX72628 AFX72629 AFX72630 AFX72631 AFX72632 AFX72633 AFX72634 AFX72635 AFX72636 AFX72637 AFX72638 AFX72639 AFX72640 AFX72641 AFX72642 AFX72643 AFX72644 AFX72645 AFX72646 AFX72647 AFX72648 AFX72649 AFX72650 AFX72651 AFX72652 AFX72653 AFX72654 AFX72655 AFX72656 AFX72657 AFX72658 AFX72659 AFX72660 AFX72661 AFX72662 AFX72663 AFX72664 AFX72665 AFX72666 AFX72667 AFX72668 AFX72669 AFX72670 AFX72671 AFX72672 AFX72673 AFX72674 AFX72675 AFX72676 AFX72677 AFX72678 AFX72679 AFX72680 AFX72681 AFX72682 AFX72683 AFX72684 AFX72685 AFX72686 AFX72687 AFX72688 AFX72689 AFX72690 AFX72691 AFX72692 AFX72693 AFX72694 AFX72695 AFX72696 AFX72697 AFX72698 AFX72699 AFX72700 AFX72701 AFX72702 AFX72703 AFX72704 AFX72705 AFX72706 BAG55021 EAX04952 EAX04953

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca