Version 5.4
Homo sapiens Protein: PLCL2
Summary
InnateDB Protein IDBP-366868.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLCL2
Protein Name phospholipase C-like 2
Synonyms PLCE2;
Species Homo sapiens
Ensembl Protein ENSP00000412836
InnateDB Gene IDBG-21444 (PLCL2)
Protein Structure
UniProt Annotation
Function May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000250}.
Subcellular Localization Cytoplasm. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0050811 GABA receptor binding
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
PFAM PF00168
PF00388
PF00387
PF00169
PF09279
PRINTS PR00360
PR00390
PIRSF
SMART SM00239
SM00148
SM00149
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UPR0
PhosphoSite PhosphoSite-Q9UPR0
TrEMBL
UniProt Splice Variant
Entrez Gene 23228
UniGene Hs.741267
RefSeq NP_055999
HUGO HGNC:9064
OMIM 614276
CCDS CCDS33713
HPRD 07147
IMGT
EMBL AB029015 AK023546 AK291419 AL117515 BC036392
GenPept AAH36392 BAA83044 BAB14606 BAF84108 CAB55974

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca