InnateDB Protein
|
IDBP-364593.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
MAVS
|
Protein Name
|
mitochondrial antiviral signaling protein
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000401980
|
InnateDB Gene
|
IDBG-49080 (MAVS)
|
Protein Structure
|
|
Function |
Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. {ECO:0000269PubMed:16125763, ECO:0000269PubMed:16127453, ECO:0000269PubMed:16153868, ECO:0000269PubMed:16177806, ECO:0000269PubMed:19631370, ECO:0000269PubMed:20451243}.
|
Subcellular Localization |
Mitochondrion outer membrane. Mitochondrion. Peroxisome.
|
Disease Associations |
|
Tissue Specificity |
Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. {ECO:0000269PubMed:16125763, ECO:0000269PubMed:16127453, ECO:0000269PubMed:16153868}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 156 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
156
[view]
|
Protein-Protein |
156
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
11 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0001934
|
positive regulation of protein phosphorylation
|
GO:0002218
|
activation of innate immune response
|
GO:0002230
|
positive regulation of defense response to virus by host
|
GO:0007165
|
signal transduction
|
GO:0016032
|
viral process
|
GO:0032480
|
negative regulation of type I interferon production
|
GO:0032481
|
positive regulation of type I interferon production
|
GO:0032727
|
positive regulation of interferon-alpha production
|
GO:0032728
|
positive regulation of interferon-beta production
|
GO:0032757
|
positive regulation of interleukin-8 production
|
GO:0032760
|
positive regulation of tumor necrosis factor production
|
GO:0033160
|
positive regulation of protein import into nucleus, translocation
|
GO:0039529
|
RIG-I signaling pathway
|
GO:0042742
|
defense response to bacterium
|
GO:0042993
|
positive regulation of transcription factor import into nucleus
|
GO:0043123
|
positive regulation of I-kappaB kinase/NF-kappaB signaling
|
GO:0045071
|
negative regulation of viral genome replication
|
GO:0045087
|
innate immune response (InnateDB)
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
GO:0051091
|
positive regulation of sequence-specific DNA binding transcription factor activity
|
GO:0051607
|
defense response to virus
|
GO:0060340
|
positive regulation of type I interferon-mediated signaling pathway
|
GO:0071360
|
cellular response to exogenous dsRNA
|
GO:0071651
|
positive regulation of chemokine (C-C motif) ligand 5 production
|
GO:0071660
|
positive regulation of IP-10 production
|
GO:1900063
|
regulation of peroxisome organization
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q7Z434
|
PhosphoSite |
PhosphoSite-Q7Z434
|
TrEMBL |
M1P2Z0
|
UniProt Splice Variant |
|
Entrez Gene |
57506
|
UniGene |
Hs.570362
|
RefSeq |
NP_065797
|
HUGO |
HGNC:29233
|
OMIM |
609676
|
CCDS |
CCDS33437
|
HPRD |
13847
|
IMGT |
|
EMBL |
AB033097
AB097003
AB232371
AK023799
AK123956
AK130992
AK291785
AK296897
AL109804
AL353194
BC044952
CH471133
DQ167126
DQ174270
DQ181928
EF467323
EF467324
KC415005
|
GenPept |
AAH44952
AAZ80417
ABA19229
ABA54890
ABR24161
ABR24162
AGF94754
BAA86585
BAB14684
BAC77356
BAC85473
BAC85734
BAE79738
BAF84474
BAG59455
CAI11041
CAI18851
EAX10481
|
|
|