InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUP50

Summary

InnateDB Protein

IDBP-295685.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUP50

Protein Name

nucleoporin 50kDa

Synonyms

NPAP60; NPAP60L;

Species

Homo sapiens

Ensembl Protein

ENSP00000385555

InnateDB Gene

IDBG-11282 (NUP50)

Protein Structure

UniProt Annotation

Function

Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin- alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B. {ECO:0000269PubMed:20016008}.

Subcellular Localization

Nucleus, nuclear pore complex {ECO:0000269PubMed:12802065}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Nucleoplasmic side {ECO:0000250}. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis. Associates to the newly formed nuclear membrane during telophase. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0007077	mitotic nuclear envelope disassembly
GO:0008645	hexose transport
GO:0010827	regulation of glucose transport
GO:0015031	protein transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0046907	intracellular transport
GO:0051028	mRNA transport
GO:0055085	transmembrane transport