InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL6

Summary

InnateDB Protein

IDBP-294916.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL6

Protein Name

interleukin 6 (interferon, beta 2)

Synonyms

BSF2; HGF; HSF; IFNB2; IL-6;

Species

Homo sapiens

Ensembl Protein

ENSP00000385675

InnateDB Gene

IDBG-9462 (IL6)

Protein Structure

UniProt Annotation

Function

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

Subcellular Localization

Secreted.

Disease Associations

Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic- onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	12 [view]
Protein-DNA	18 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005138	interleukin-6 receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001781	neutrophil apoptotic process
GO:0002384	hepatic immune response
GO:0002446	neutrophil mediated immunity
GO:0002548	monocyte chemotaxis
GO:0002675	positive regulation of acute inflammatory response
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0006469	negative regulation of protein kinase activity
GO:0006953	acute-phase response
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006959	humoral immune response
GO:0007568	aging
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0009408	response to heat
GO:0009409	response to cold
GO:0009611	response to wounding
GO:0009612	response to mechanical stimulus
GO:0009617	response to bacterium
GO:0010574	regulation of vascular endothelial growth factor production
GO:0010628	positive regulation of gene expression
GO:0010888	negative regulation of lipid storage
GO:0010996	response to auditory stimulus
GO:0014070	response to organic cyclic compound
GO:0016049	cell growth
GO:0019221	cytokine-mediated signaling pathway
GO:0030168	platelet activation
GO:0031000	response to caffeine
GO:0031018	endocrine pancreas development
GO:0031175	neuron projection development
GO:0031667	response to nutrient levels
GO:0032494	response to peptidoglycan
GO:0032496	response to lipopolysaccharide
GO:0032722	positive regulation of chemokine production
GO:0032755	positive regulation of interleukin-6 production
GO:0032868	response to insulin
GO:0032966	negative regulation of collagen biosynthetic process
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0034097	response to cytokine
GO:0042060	wound healing
GO:0042102	positive regulation of T cell proliferation
GO:0042110	T cell activation
GO:0042127	regulation of cell proliferation
GO:0042493	response to drug
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042832	defense response to protozoan
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043200	response to amino acid
GO:0043410	positive regulation of MAPK cascade
GO:0045079	negative regulation of chemokine biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045454	cell redox homeostasis
GO:0045599	negative regulation of fat cell differentiation
GO:0045630	positive regulation of T-helper 2 cell differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045721	negative regulation of gluconeogenesis
GO:0045727	positive regulation of translation
GO:0045740	positive regulation of DNA replication
GO:0045765	regulation of angiogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046427	positive regulation of JAK-STAT cascade
GO:0046677	response to antibiotic
GO:0046716	muscle cell cellular homeostasis
GO:0046849	bone remodeling
GO:0046888	negative regulation of hormone secretion
GO:0048635	negative regulation of muscle organ development
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050710	negative regulation of cytokine secretion
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0050871	positive regulation of B cell activation
GO:0051024	positive regulation of immunoglobulin secretion
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384	response to glucocorticoid
GO:0051592	response to calcium ion
GO:0051602	response to electrical stimulus
GO:0051607	defense response to virus
GO:0051897	positive regulation of protein kinase B signaling
GO:0051971	positive regulation of transmission of nerve impulse
GO:0060445	branching involved in salivary gland morphogenesis
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis
GO:0070091	glucagon secretion
GO:0070102	interleukin-6-mediated signaling pathway
GO:0070301	cellular response to hydrogen peroxide
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071222	cellular response to lipopolysaccharide
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071549	cellular response to dexamethasone stimulus
GO:0072540	T-helper 17 cell lineage commitment
GO:1901215	negative regulation of neuron death
GO:2000366	positive regulation of STAT protein import into nucleus
GO:2000676	positive regulation of type B pancreatic cell apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005896	interleukin-6 receptor complex
GO:0009897	external side of plasma membrane