Version 5.4
Mus musculus Protein: Tlr4
Summary
InnateDB Protein IDBP-266823.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Tlr4
Protein Name toll-like receptor 4
Synonyms Lps; Ly87; Ran/M1; Rasl2-8;
Species Mus musculus
Ensembl Protein ENSMUSP00000102988
InnateDB Gene IDBG-156729 (Tlr4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
Experimentally validated
Total 59 [view]
Protein-Protein 54 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 58 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002218 activation of innate immune response
GO:0002322 B cell proliferation involved in immune response
GO:0002537 nitric oxide production involved in inflammatory response
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0009617 response to bacterium
GO:0030890 positive regulation of B cell proliferation
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032609 interferon-gamma production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0034142 toll-like receptor 4 signaling pathway
GO:0042116 macrophage activation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045359 positive regulation of interferon-beta biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0046330 positive regulation of JNK cascade
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050707 regulation of cytokine secretion
GO:0050829 defense response to Gram-negative bacterium
GO:0060907 positive regulation of macrophage cytokine production
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070430 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
Cellular Component
GO:0046696 lipopolysaccharide receptor complex
Protein Structure and Domains
PDB ID MGI:96824
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A2BHU8
UniProt Splice Variant
Entrez Gene 21898
UniGene Mm.418171
RefSeq
MGI ID
MGI Symbol Tlr4
OMIM
CCDS
HPRD
IMGT
EMBL AL805946 BX649609
GenPept CAD83014

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca