InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP25

Summary

InnateDB Protein

IDBP-228825.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP25

Protein Name

ubiquitin specific peptidase 25

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000383044

InnateDB Gene

IDBG-805 (USP25)

Protein Structure

UniProt Annotation

Function

Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16501887, ECO:0000269PubMed:19440361}.Isoform USP25m: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Some transient punctuate nuclear location in myotubes during myocyte development. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform USB25a is found in most adult and fetal tissues; expression is moderately high in testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood, colon, small intestine, ovary, prostate, thymus and spleen. Isoform USB25b is found in all tissues except heart and skeletal muscle. Isoform USB25m is heart and skeletal muscle specific. {ECO:0000269PubMed:10644437, ECO:0000269PubMed:11597335}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0032183	SUMO binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0070536	protein K63-linked deubiquitination
GO:0071108	protein K48-linked deubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR003903 Ubiquitin interacting motif
IPR009060 UBA-like
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443
PF02809

PRINTS

PIRSF

SMART

SM00726

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UHP3