InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPM1F

Summary

InnateDB Protein

IDBP-2165.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPM1F

Protein Name

protein phosphatase, Mg2+/Mn2+ dependent, 1F

Synonyms

CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2;

Species

Homo sapiens

Ensembl Protein

ENSP00000263212

InnateDB Gene

IDBG-2163 (PPM1F)

Protein Structure

UniProt Annotation

Function

Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0033192	calmodulin-dependent protein phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0010628	positive regulation of gene expression
GO:0010634	positive regulation of epithelial cell migration
GO:0010811	positive regulation of cell-substrate adhesion
GO:0016576	histone dephosphorylation
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0035690	cellular response to drug
GO:0035970	peptidyl-threonine dephosphorylation
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045927	positive regulation of growth
GO:0050921	positive regulation of chemotaxis
GO:0051496	positive regulation of stress fiber assembly
GO:0051894	positive regulation of focal adhesion assembly
GO:0097193	intrinsic apoptotic signaling pathway