Version 5.4
Mus musculus Protein: Chst12
Summary
InnateDB Protein IDBP-206944.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chst12
Protein Name carbohydrate sulfotransferase 12
Synonyms AI595374; C4S-2; C4ST2;
Species Mus musculus
Ensembl Protein ENSMUSP00000041663
InnateDB Gene IDBG-206942 (Chst12)
Protein Structure
UniProt Annotation
Function Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0047756 chondroitin 4-sulfotransferase activity
Biological Process
GO:0016051 carbohydrate biosynthetic process
GO:0030206 chondroitin sulfate biosynthetic process
GO:0030208 dermatan sulfate biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1929064
InterPro IPR005331 Sulfotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF03567
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99LL3
PhosphoSite PhosphoSite-Q99LL3
TrEMBL D3YUY0
UniProt Splice Variant
Entrez Gene 59031
UniGene Mm.28934
RefSeq NP_067503
MGI ID
MGI Symbol Chst12
OMIM
CCDS CCDS19820
HPRD
IMGT
EMBL AC117602 AJ289132 AK142155 AK170484 AK171208 BC003201 CH466529
GenPept AAH03201 BAE24951 BAE41826 BAE42314 CAB92140 EDL19118

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca