InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tet2

Summary

InnateDB Protein

IDBP-195029.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tet2

Protein Name

tet oncogene family member 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096203

InnateDB Gene

IDBG-195027 (Tet2)

Protein Structure

UniProt Annotation

Function

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269PubMed:20639862, ECO:0000269PubMed:21057493, ECO:0000269PubMed:21778364, ECO:0000269PubMed:21817016, ECO:0000269PubMed:23352454, ECO:0000269PubMed:23353889}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in the brain, kidney, heart, lung, muscle and stomach. Present in embryonic stem cells (ES cells). {ECO:0000269PubMed:16722336, ECO:0000269PubMed:20639862}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	35 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008198	ferrous iron binding
GO:0008270	zinc ion binding
GO:0070579	methylcytosine dioxygenase activity

Biological Process

GO:0001822	kidney development
GO:0006211	5-methylcytosine catabolic process
GO:0006493	protein O-linked glycosylation
GO:0007049	cell cycle
GO:0009791	post-embryonic development
GO:0030097	hemopoiesis
GO:0030099	myeloid cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0055114	oxidation-reduction process
GO:0080111	DNA demethylation
GO:0080182	histone H3-K4 trimethylation