Version 5.4
Mus musculus Protein: Ubxn6
Summary
InnateDB Protein IDBP-191530.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ubxn6
Protein Name UBX domain protein 6
Synonyms 1200008L11Rik; 2210415J11Rik; AU040909; Ubxd1; Ubxdc2;
Species Mus musculus
Ensembl Protein ENSMUSP00000019722
InnateDB Gene IDBG-191528 (Ubxn6)
Protein Structure
UniProt Annotation
Function Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes at the centrosome both in interphase and during mitosis. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed (at protein level). Highest expression in brain (at protein level). {ECO:0000269PubMed:18656546}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1913780
InterPro IPR001012 UBX domain
IPR006567 PUG domain
IPR018997 PUB domain
IPR029071 Ubiquitin-related domain
PFAM PF00789
PF09409
PRINTS
PIRSF
SMART SM00166
SM00580
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99PL6
PhosphoSite PhosphoSite-Q99PL6
TrEMBL
UniProt Splice Variant
Entrez Gene 66530
UniGene Mm.28000
RefSeq NP_077752
MGI ID
MGI Symbol Ubxn6
OMIM
CCDS CCDS28893
HPRD
IMGT
EMBL AF272895 AK009117 AK082510 AK148170 AK161273 BC016412 BC049963 CH466559 CT009719
GenPept AAH16412 AAH49963 AAK13259 BAB26082 BAC38512 BAE28390 BAE36284 CAX15602 EDL23709

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca