Version 5.4
Homo sapiens Protein: UBXN6
Summary
InnateDB Protein IDBP-18961.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBXN6
Protein Name UBX domain protein 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000301281
InnateDB Gene IDBG-18959 (UBXN6)
Protein Structure
UniProt Annotation
Function Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation. {ECO:0000269PubMed:18768758}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:18656546}. Nucleus {ECO:0000269PubMed:18656546}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:18656546}. Note=Localizes at the centrosome both in interphase and during mitosis.
Disease Associations
Tissue Specificity Enhanced expression in testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001012 UBX domain
IPR006567 PUG domain
IPR018997 PUB domain
IPR029071 Ubiquitin-related domain
PFAM PF00789
PF09409
PRINTS
PIRSF
SMART SM00166
SM00580
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BZV1
PhosphoSite PhosphoSite-Q9BZV1
TrEMBL
UniProt Splice Variant
Entrez Gene 80700
UniGene Hs.609016
RefSeq NP_079517
HUGO HGNC:14928
OMIM 611946
CCDS CCDS12129
HPRD 18253
IMGT
EMBL AF272893 AF272894 BC007414 BC008288 BC017113 CH471139
GenPept AAH07414 AAH08288 AAH17113 AAK13257 AAK13258 EAW69219 EAW69222

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca