Version 5.4
Mus musculus Protein: Scg3
Summary
InnateDB Protein IDBP-185478.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scg3
Protein Name secretogranin III
Synonyms 1B1075; AI385542; Chgd; SgIII;
Species Mus musculus
Ensembl Protein ENSMUSP00000034699
InnateDB Gene IDBG-185476 (Scg3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasmic vesicle, secretory vesicle {ECO:0000269PubMed:12388744}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000269PubMed:12388744}. Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts in intragranular conditions. In neuroblastoma cells, colocalizes with PMCH, NPY, POMC and orexin/HCRT in secretory granules.
Disease Associations
Tissue Specificity Expressed in various brain areas, with highest levels in the arcuate nucleus and the lateral hypothalamic area, as well as the paraventricular nucleus and the ventromedial hypothalamus (at protein level). {ECO:0000269PubMed:17200173}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
Cellular Component
GO:0005576 extracellular region
GO:0030658 transport vesicle membrane
Protein Structure and Domains
PDB ID MGI:103032
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P47867
PhosphoSite PhosphoSite-P47867
TrEMBL
UniProt Splice Variant
Entrez Gene 20255
UniGene Mm.2386
RefSeq NP_033156
MGI ID
MGI Symbol Scg3
OMIM
CCDS CCDS23347
HPRD
IMGT
EMBL AK133655 AK139140 AK158315 AK164089 BC024785 CH466522 U02982
GenPept AAA56636 AAH24785 BAE21767 BAE23899 BAE34456 BAE37620 EDL26334

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca