Version 5.4
Homo sapiens Protein: LMCD1
Summary
InnateDB Protein IDBP-14744.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LMCD1
Protein Name LIM and cysteine-rich domains 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000157600
InnateDB Gene IDBG-14742 (LMCD1)
Protein Structure
UniProt Annotation
Function Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. {ECO:0000250, ECO:0000269PubMed:20026769}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=May shuttle between the cytoplasm and the nucleus. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in skeletal muscle. {ECO:0000269PubMed:20026769}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0010611 regulation of cardiac muscle hypertrophy
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR001781 Zinc finger, LIM-type
IPR010442 PET domain
PFAM PF00412
PF06297
PRINTS
PIRSF
SMART SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZU5
PhosphoSite PhosphoSite-Q9NZU5
TrEMBL
UniProt Splice Variant
Entrez Gene 29995
UniGene
RefSeq NP_055398
HUGO HGNC:6633
OMIM 604859
CCDS CCDS33688
HPRD 06891
IMGT
EMBL AC087859 AF169284 AF216709 AK022176 AK294455 BC000646
GenPept AAF34411 AAG36778 AAH00646 BAB13976 BAG57691

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca