InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tssk2

Summary

InnateDB Protein

IDBP-140753.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tssk2

Protein Name

testis-specific serine kinase 2

Synonyms

DGS-G; SPOGA2; Stk22b; Tsk2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051035

InnateDB Gene

IDBG-140751 (Tssk2)

Protein Structure

UniProt Annotation

Function

Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-281' of TSKS and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. {ECO:0000269PubMed:18367677, ECO:0000269PubMed:18533145, ECO:0000269PubMed:20053632, ECO:0000269PubMed:9412477}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment. In spermatids, concentrates in centrioles during flagellogenesis. Localizes in the tail and acrosomal regions of epididymal sperm.

Disease Associations

Tissue Specificity

Testis-specific. Expressed only in the spermatids postmeiotically at the final stages of cytodifferentiation in the seminiferous tubules (at protein level). Not detected in released sperms in the lumen of the seminiferous tubules. Also present in the epididymal sperm (at protein level). {ECO:0000269PubMed:18533145, ECO:0000269PubMed:20729278, ECO:0000269PubMed:9412477, ECO:0000269PubMed:9651519}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007275	multicellular organismal development
GO:0007286	spermatid development
GO:0046777	protein autophosphorylation

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005814	centriole

Protein Structure and Domains

PDB ID

MGI:1347559

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt