Version 5.4
Mus musculus Protein: Cfl2
Summary
InnateDB Protein IDBP-139809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cfl2
Protein Name cofilin 2, muscle
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000077262
InnateDB Gene IDBG-139807 (Cfl2)
Protein Structure
UniProt Annotation
Function Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
Subcellular Localization Nucleus matrix. Cytoplasm, cytoskeleton.
Disease Associations
Tissue Specificity Predominantly expressed in skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0007015 actin filament organization
GO:0030042 actin filament depolymerization
GO:0030836 positive regulation of actin filament depolymerization
GO:0045214 sarcomere organization
GO:0046716 muscle cell cellular homeostasis
GO:0061001 regulation of dendritic spine morphogenesis
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0016363 nuclear matrix
GO:0031674 I band
Protein Structure and Domains
PDB ID MGI:101763
InterPro IPR002108 Actin-depolymerising factor homology domain
IPR017904 ADF/Cofilin/Destrin
PFAM PF00241
PRINTS PR00006
PIRSF
SMART SM00102
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P45591
PhosphoSite PhosphoSite-P45591
TrEMBL Q3UHW9
UniProt Splice Variant
Entrez Gene 12632
UniGene Mm.472326
RefSeq NP_031714
MGI ID
MGI Symbol Cfl2
OMIM
CCDS CCDS36448
HPRD
IMGT
EMBL AK147174 BC007138 L29468
GenPept AAA37433 AAH07138 BAE27737

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca