InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map3k11

Summary

InnateDB Protein

IDBP-132708.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map3k11

Protein Name

mitogen-activated protein kinase kinase kinase 11

Synonyms

2610017K16Rik; Mlk3; PTK1; SPRK;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004156

InnateDB Gene

IDBG-132706 (Map3k11)

Protein Structure

UniProt Annotation

Function

Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Location is cell cycle dependent. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004706	JUN kinase kinase kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0048365	Rac GTPase binding

Biological Process

GO:0000080	mitotic G1 phase
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0007017	microtubule-based process
GO:0007254	JNK cascade
GO:0007256	activation of JNKK activity
GO:0007257	activation of JUN kinase activity
GO:0008219	cell death
GO:0008283	cell proliferation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043065	positive regulation of apoptotic process
GO:0043507	positive regulation of JUN kinase activity
GO:0043525	positive regulation of neuron apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005874	microtubule
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1346880

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR016231 Mitogen-activated protein (MAP) kinase kinase kinase, 9/10/11
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00018
PF14604
PF07653

PRINTS

PR00109
PR00452

PIRSF

PIRSF000556

SMART

SM00326
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References