InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnahc5

Summary

InnateDB Protein

IDBP-132067.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnahc5

Protein Name

dynein, axonemal, heavy chain 5

Synonyms

AU022615; b2b1134Clo; b2b1154Clo; b2b1537Clo; b2b1565Clo; b2b601Clo; Dnahc5; Mdnah5; mKIAA1603;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069751

InnateDB Gene

IDBG-132065 (Dnahc5)

Protein Structure

UniProt Annotation

Function

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles. {ECO:0000269PubMed:15269178}.

Subcellular Localization

Cytoplasm, cytoskeleton, cilium axoneme.

Disease Associations

Note=Defects in Dnah5 are the cause of primary ciliary dyskinesia (PCD). PCD is characterized by recurrent respiratory infections, situs inversus and ciliary immotility and hydrocephalus. {ECO:0000269PubMed:11912187}.

Tissue Specificity

Strongly expressed in lung and kidney and weaker expression seen in brain, heart and testis. In the brain, expressed in ependymal cells lining the brain ventricles and the aqueduct. {ECO:0000269PubMed:11788826, ECO:0000269PubMed:15269178}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0003341	cilium movement
GO:0006200	ATP catabolic process
GO:0007018	microtubule-based movement
GO:0008152	metabolic process
GO:0021670	lateral ventricle development
GO:0070986	left/right axis specification

Cellular Component

GO:0005858	axonemal dynein complex
GO:0005874	microtubule
GO:0005930	axoneme
GO:0030286	dynein complex

Protein Structure and Domains

PDB ID

MGI:107718

InterPro

IPR003593 AAA+ ATPase domain
IPR004273 Dynein heavy chain domain
IPR011704 ATPase, dynein-related, AAA domain
IPR013594 Dynein heavy chain, domain-1
IPR013602 Dynein heavy chain, domain-2
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF03028
PF07728
PF08385
PF08393

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VHE6