InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Colec12

Summary

InnateDB Protein

IDBP-128249.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Colec12

Protein Name

collectin sub-family member 12

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043220

InnateDB Gene

IDBG-128247 (Colec12)

Protein Structure

UniProt Annotation

Function

Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells (By similarity). Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Forms clusters on the cell surface. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in vascular endothelial cells in the heart, in perivascular macrophage and smooth muscle cells. Expressed in plaques-surrounding reactive astrocytes located in cerebral cortex and hippocampus and in leptomeningeal vessels showing characteristics of cerebral amyloid angiopathy (CAA) in a double transgenic mouse model of Alzheimer disease (at protein level). Strongly expressed in lung. Moderately expressed in heart, skeletal muscle, spleen, liver, brain, colon, testis, stomach and kidney. Expressed in neonatal astrocytes. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of a double transgenic mouse model of Alzheimer disease. {ECO:0000269PubMed:11564734, ECO:0000269PubMed:11718900, ECO:0000269PubMed:16868960}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008329	signaling pattern recognition receptor activity
GO:0030169	low-density lipoprotein particle binding
GO:0030246	carbohydrate binding
GO:0046872	metal ion binding