InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCUBE1

Summary

InnateDB Protein

IDBP-10605.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCUBE1

Protein Name

signal peptide, CUB domain, EGF-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000354080

InnateDB Gene

IDBG-10601 (SCUBE1)

Protein Structure

UniProt Annotation

Function

Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. {ECO:0000269PubMed:16753137}.

Subcellular Localization

Secreted. Cell membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being released from the storage granules, is associated with thrombus and localized with the subendothelial matrices in atherosclerotic plaques. {ECO:0000269PubMed:12270931, ECO:0000269PubMed:16753137}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006954	inflammatory response
GO:0007512	adult heart development
GO:0007596	blood coagulation
GO:0009791	post-embryonic development
GO:0045446	endothelial cell differentiation
GO:0051260	protein homooligomerization

Cellular Component

GO:0005615	extracellular space
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0019897	extrinsic component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000859 CUB domain
IPR001881 EGF-like calcium-binding domain
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like

PFAM

PF00008
PF00431
PF07645
PF07699

PRINTS

PIRSF

SMART

SM00181
SM00042
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IWY4