Homo sapiens Gene: HDAC2
Summary
InnateDB Gene IDBG-95591.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDAC2
Gene Name histone deacetylase 2
Synonyms HD2; RPD3; YAF1;
Species Homo sapiens
Ensembl Gene ENSG00000196591
Encoded Proteins
histone deacetylase 2
histone deacetylase 2
histone deacetylase 2
histone deacetylase 2
histone deacetylase 2
histone deacetylase 2
histone deacetylase 2
histone deacetylase 2
histone deacetylase 2
histone deacetylase 2
histone deacetylase 2
histone deacetylase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Histone deacetylase 2 (HDAC2) is part of a repressor complex, along with key components that include HDAC1, RE-1 silencing transcription factor (REST), co-repressor of REST (CoREST), and lysine-specific demethylase (LSD) 1. The HDAC/CoREST/REST/LSD1 repressor complex is a significant component of host innate immunity.
TET2 selectively mediates active repression of IL6 transcription via NFKBIZ and HDAC2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Tet2 selectively mediates active repression of Il6 transcription via Nfkbiz and Hdac2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
Entrez Gene
Summary This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:113933028-114011308
Strand Reverse strand
Band q21
Transcripts
ENST00000368632 ENSP00000357621
ENST00000425835 ENSP00000417026
ENST00000519065 ENSP00000430432
ENST00000523334
ENST00000519108 ENSP00000430008
ENST00000520746
ENST00000518756
ENST00000523628 ENSP00000427861
ENST00000521610 ENSP00000429901
ENST00000522371 ENSP00000428599
ENST00000521163 ENSP00000428024
ENST00000518690 ENSP00000428653
ENST00000523240 ENSP00000429236
ENST00000521233
ENST00000520895 ENSP00000428861
ENST00000524334 ENSP00000428989
ENST00000520170
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 502 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.
Experimentally validated
Total 502 [view]
Protein-Protein 391 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 102 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 56 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019213 deacetylase activity
GO:0019899 enzyme binding
GO:0031072 heat shock protein binding
GO:0031490 chromatin DNA binding
GO:0031492 nucleosomal DNA binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558 protein deacetylase activity
GO:0035851 Krueppel-associated box domain binding
GO:0043565 sequence-specific DNA binding
GO:0044822 poly(A) RNA binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006338 chromatin remodeling
GO:0006344 maintenance of chromatin silencing
GO:0006351 transcription, DNA-templated
GO:0006476 protein deacetylation
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0009913 epidermal cell differentiation
GO:0010870 positive regulation of receptor biosynthetic process
GO:0010977 negative regulation of neuron projection development
GO:0016358 dendrite development
GO:0016575 histone deacetylation
GO:0021766 hippocampus development
GO:0030182 neuron differentiation
GO:0032922 circadian regulation of gene expression
GO:0032967 positive regulation of collagen biosynthetic process
GO:0034605 cellular response to heat
GO:0042220 response to cocaine
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042493 response to drug
GO:0042733 embryonic digit morphogenesis
GO:0043044 ATP-dependent chromatin remodeling
GO:0043066 negative regulation of apoptotic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087 innate immune response (InnateDB)
GO:0045347 negative regulation of MHC class II biosynthetic process
GO:0045786 negative regulation of cell cycle
GO:0045862 positive regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051896 regulation of protein kinase B signaling
GO:0055013 cardiac muscle cell development
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060297 regulation of sarcomere organization
GO:0060789 hair follicle placode formation
GO:0061029 eyelid development in camera-type eye
GO:0061198 fungiform papilla formation
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090311 regulation of protein deacetylation
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0017053 transcriptional repressor complex
GO:0035098 ESC/E(Z) complex
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Notch pathway
TNFalpha pathway
REACTOME
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Signalling by NGF pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
RNA Polymerase I Transcription pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signaling by NOTCH1 in Cancer pathway
p75NTR negatively regulates cell cycle via SC1 pathway
Epigenetic regulation of gene expression pathway
p75 NTR receptor-mediated signalling pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
Signal Transduction pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
HDACs deacetylate histones pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Chromatin organization pathway
Signaling by NOTCH pathway
RNA Polymerase I Transcription Initiation pathway
Factors involved in megakaryocyte development and platelet production pathway
Chromatin modifying enzymes pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Gene Expression pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
Negative epigenetic regulation of rRNA expression pathway
Hemostasis pathway
KEGG
Cell cycle pathway
Notch signaling pathway pathway
Huntington's disease pathway
Pathways in cancer pathway
Chronic myeloid leukemia pathway
INOH
TGF-beta signaling pathway
PID BIOCARTA
The prc2 complex sets long-term gene silencing through modification of histone tails [Biocarta view]
Mechanisms of transcriptional repression by dna methylation [Biocarta view]
Mets affect on macrophage differentiation [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
PID NCI
Direct p53 effectors
Signaling events mediated by HDAC Class I
Glucocorticoid receptor regulatory network
Regulation of nuclear SMAD2/3 signaling
Hedgehog signaling events mediated by Gli proteins
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.3352
RefSeq NM_001527
HUGO
OMIM
CCDS CCDS43493
HPRD 05521
IMGT
EMBL
GenPept
RNA Seq Atlas