Mus musculus Gene: Il22
Summary
InnateDB Gene IDBG-72289.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Il22
Gene Name Interleukin-22
Synonyms IL-22; IL-22a; Iltif; ILTIFa
Species Mus musculus
Ensembl Gene ENSMUSG00000074695
Encoded Proteins
Interleukin-22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Iltifb (Il22b) increases the TNF-alpha-dependent induction and secretion of several immune-modulatory molecules such as initial complement factors, antimicrobial peptides and chemokines in primary keratinocytes. Iltifb-mediated induction of innate immunity is crucial for the maintenance of epidermal integrity during infection with Candida albicans. (Demonstrated in human)
Iltifb (Il22) is produced by lymphoid tissue-inducer cells where it regulates the maintenance of colonic lymphoid structures during Citrobacter rodentium infection, a mechanism that bridges the lymphotoxin pathway to mucosal epithelial defense mechanisms.
ILTIFB (IL22) protects intestinal stem cells from inflammatory tissue damage and regulates sensitivity to graft versus host disease. (Demonstrated in human)
Flagellin induces Tlr5-dependent Il22 production and Nlrc4-dependent Il18 production to promote a protective gene expression program in intestinal epithelial cells and elimination of rotavirus-infected cells.
Cxcl16-Cxcr6 crosstalk coordinates the intestinal topography of Il22 secretion required for mucosal defence against Citrobacter rodentium infection.
Il22 augments the expression of Il18 mRNA and inactive precursor protein (proIL-18) in intestinal epithelial cells after Toxoplasma gondii or Citrobacter rodentium infection and maintains the homeostatic amount of proIL-18 in the ileum.
Innate lymphoid cells, potent producers of Il22 after intestinal injury, increase the growth of mouse small intestine organoids in an Il22-dependent fashion.
Group 3 innate lymphoid cells (ILC3s) can mediate immune surveillance, which constantly maintains a proper microbiota, to facilitate early colonization resistance through an Id2-dependent regulation of Il22.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:118204942-118210047
Strand Forward strand
Band D2
Transcripts
ENSMUST00000096691 ENSMUSP00000094449
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
Biological Process
GO:0010469 regulation of receptor activity
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050728 negative regulation of inflammatory response
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Interleukin-20 family signaling pathway
Signaling by Interleukins pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Th17 cell differentiation pathway
Inflammatory bowel disease (IBD) pathway
INOH
PID NCI
Cross-References
SwissProt Q9JJY9
TrEMBL
UniProt Splice Variant
Entrez Gene 50929
UniGene
RefSeq NM_016971 XM_006513865
OMIM
CCDS CCDS36070
HPRD
IMGT
MGI ID MGI:1355307
MGI Symbol Il22
EMBL AJ249491 AJ294727 BC116235
GenPept AAI16236 CAB75546 CAC19435
RNA Seq Atlas 50929