|Mus musculus Gene: Il22|
|Last Modified||2018-06-05 [Report errors or provide feedback]|
|Synonyms||IL-22; IL-22a; Iltif; ILTIFa|
|Useful resources||Stemformatics EHFPI ImmGen|
Iltifb (Il22b) increases the TNF-alpha-dependent induction and secretion of several immune-modulatory molecules such as initial complement factors, antimicrobial peptides and chemokines in primary keratinocytes. Iltifb-mediated induction of innate immunity is crucial for the maintenance of epidermal integrity during infection with Candida albicans. (Demonstrated in human)
Iltifb (Il22) is produced by lymphoid tissue-inducer cells where it regulates the maintenance of colonic lymphoid structures during Citrobacter rodentium infection, a mechanism that bridges the lymphotoxin pathway to mucosal epithelial defense mechanisms.
ILTIFB (IL22) protects intestinal stem cells from inflammatory tissue damage and regulates sensitivity to graft versus host disease. (Demonstrated in human)
Flagellin induces Tlr5-dependent Il22 production and Nlrc4-dependent Il18 production to promote a protective gene expression program in intestinal epithelial cells and elimination of rotavirus-infected cells.
Cxcl16-Cxcr6 crosstalk coordinates the intestinal topography of Il22 secretion required for mucosal defence against Citrobacter rodentium infection.
Il22 augments the expression of Il18 mRNA and inactive precursor protein (proIL-18) in intestinal epithelial cells after Toxoplasma gondii or Citrobacter rodentium infection and maintains the homeostatic amount of proIL-18 in the ileum.
Innate lymphoid cells, potent producers of Il22 after intestinal injury, increase the growth of mouse small intestine organoids in an Il22-dependent fashion.
Group 3 innate lymphoid cells (ILC3s) can mediate immune surveillance, which constantly maintains a proper microbiota, to facilitate early colonization resistance through an Id2-dependent regulation of Il22.
|Summary||Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.|
|Genomic Location||Chromosome 10:118204942-118210047|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
|No orthologs found for this gene|
Interleukin-20 family signaling pathway
Signaling by Interleukins pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Th17 cell differentiation pathway
Inflammatory bowel disease (IBD) pathway
|UniProt Splice Variant|
|EMBL||AJ249491 AJ294727 BC116235|
|GenPept||AAI16236 CAB75546 CAC19435|
|RNA Seq Atlas||50929|