Mus musculus Gene: Mir146
Summary
InnateDB Gene IDBG-70068.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Mir146
Gene Name microRNA 146
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000065601
Encoded Proteins
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Mir146 directly targets Relb to modulate the amplitude of monocyte responses to inflammatory challenges.
Mir146 is a mechanosensitive miRNA that modulates mechanotransduction and pressure-induced inflammation in small airway epithelium. (Demonstrated in human)
Nod2 driven inflammation is regulated by nitric oxide responsive Mir146 that facilitates activation of sonic hedgehog (SHH) signalling by targeting Numb expression.
T-cell-intrinsic Mir155 is required for type-2 immunity, in part through regulation of S1pr1, whereas T-cell-intrinsic Mir146 is required to prevent overt Th1/Th17 skewing.
Mir146 attenuates sepsis-induced cardiac dysfunction by preventing NFκB activation, inflammatory cell infiltration, and inflammatory cytokine production via targeting of Irak1 and Traf6 in both cardiomyocytes and inflammatory monocytic cells.
Mir146 has a role in constraining intestinal barrier function, a process that alters gut homeostasis and increases susceptibility to dextran sodium sulphate-induced colitis.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type miRNA
Genomic Location Chromosome 11:43374397-43374461
Strand Reverse strand
Band B1.1
Transcripts
ENSMUST00000083667
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 2 [view]
DNA-RNA 1 [view]
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
OMIM
CCDS
HPRD
IMGT
MGI ID MGI:2676831
MGI Symbol Mir146
EMBL
GenPept
RNA Seq Atlas