Mus musculus Gene: Ifnb1
Summary
InnateDB Gene IDBG-65728.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Ifnb1
Gene Name interferon beta 1, fibroblast
Synonyms Ifb; IFN-beta; IFNB
Species Mus musculus
Ensembl Gene ENSMUSG00000048806
Encoded Proteins
interferon beta 1, fibroblast
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Ifnb1 deficiency results in a partial suppression of the sterol pathway in macrophages during viral infections, thereby linking the regulation of lipid metabolism pathway with interferon anti-viral defence responses.
Ifnb1 secretion is greater upon viable E. coli infection in comparison to heat killed E. coli vaccine or LPS. The induction of Ifnb1 is dependent on Ticam1-Irf3 signalling.
Ifnb1 expression pattern during viral infection is a highly stochastic process influenced by cell-to-cell variability in viral induction processes.
Ifnb1 production is fundamental to the efficient control of Listeria monocytogenes during the early innate phase of infection. NK cells treated with Ifnb1 during early infection were able to reduce bacterial titer in the spleen and significantly improve survival of infected mice.
The noncanonical NFκB pathway regulates histone modifications at the Ifnb1 promoter resulting in attenuated recruitment of Rela and histone demethylase, Kdm4a, to the Ifnb1 promoter. This provides a mechanism for regulating the induction of type I interferons .
The innate immune system plays a role in immunogenic tumour recognition. Tumor-cell-derived DNA triggers Ifnb1 production and dendritic cell activation via Tmem173 and Irf3 cytosolic DNA sensing pathways.
Ifnb1 selectively restricts the transcriptional responses mediated by both the TLRs and the NOD-like receptors in Salmonella enterica serovar Typhimurium infection in macrophages.
Atf3 plays an important role in modulating IFN responses in macrophages by controlling basal and inducible levels of Ifnb1, as well as the expression of genes downstream of IFN signalling.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] IFNB1 has an essential role in the anti-viral response and optineurin (OPTN) has a role in the inhibition of virus-triggered IFNB1 induction.
[Homo sapiens] Viral RNA-induced IFNB1 production is suppressed by oncogenic RAS through negative regulation of RIG-I signalling, leading to promotion of virus spread.
[Homo sapiens] IFNB1 expression is inhibited by influenza A virus polymerase by binding to IFN-beta promoter stimulator 1 (MAVS).
[Homo sapiens] IFNB1 is a type I interferon (IFN-I) and the IFN-I family comprises a wide number of cytokines with different modulatory effects on angiogenesis, cell growth, fibrosis, apoptosis and autoimmunity.
[Homo sapiens] IFNB1 deficiency results in a partial suppression of the sterol pathway in macrophages during viral infections, thereby linking the regulation of lipid metabolism pathway with interferon anti-viral defence responses. (Demonstrated in murine model)
[Homo sapiens] IFNB1 secretion is greater upon viable E. coli infection in comparison to heat killed E. coli vaccine or LPS. The induction of IFNB1 is dependent on TICAM1-IRF3 signalling. (Demonstrated in murine model).
[Homo sapiens] IFNB1 expression pattern during viral infection is a highly stochastic process influenced by cell-to-cell variability in viral induction processes. (Demonstrated in mice)
[Homo sapiens] IFNB1 production is fundamental to the efficient control of Listeria monocytogenes during the early innate phase of infection. NK cells treated with IFNB1 during early infection were able to reduce bacterial titer in the spleen and significantly improve survival of infected mice. (Demonstrated in mouse)
[Homo sapiens] Macrocyclic NS3-4A resistance-associated amino acid variants (RAVs) with substitutions at residue D168 of the hepatitis C virus protease result in an increased capacity of NS3-4A to cleave MAVS and suppress IFNB1 induction.
[Homo sapiens] Coronavirus engages papain-like proteases to escape from the innate antiviral response of the host by inhibiting TP53-IRF7-IFNB1 signalling.
[Homo sapiens] Hepatitis B virus (HBV) polymerase inhibits TMEM173-stimulated IRF3 activation and IFNB1 induction.
[Homo sapiens] ELAVL1 is required for the stabilization of IFNB1 mRNA, and suppression of ELAVL1 leads to impaired expression of IFNB1 in response to poly(I:C) treatment.
[Homo sapiens] IFNB1 selectively restricts the transcriptional responses mediated by both the TLRs and the NOD-like receptors in Salmonella enterica serovar Typhimurium infection in macrophages.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171855:
This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:88522025-88522774
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000055671 ENSMUSP00000056720
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 0
Protein-DNA 14 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005132 type I interferon receptor binding
GO:0008811 chloramphenicol O-acetyltransferase activity
Biological Process
GO:0002250 adaptive immune response
GO:0002286 T cell activation involved in immune response
GO:0002312 B cell activation involved in immune response
GO:0002323 natural killer cell activation involved in immune response
GO:0006952 defense response
GO:0006959 humoral immune response
GO:0010469 regulation of receptor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0030183 B cell differentiation
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0035458 cellular response to interferon-beta
GO:0042100 B cell proliferation
GO:0042742 defense response to bacterium
GO:0043330 response to exogenous dsRNA
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0045581 negative regulation of T cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0071359 cellular response to dsRNA
GO:0071549 cellular response to dexamethasone stimulus
GO:0098586 cellular response to virus
GO:2000552 negative regulation of T-helper 2 cell cytokine production
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Regulation of IFNA signaling pathway
Immune System pathway
KEGG
Cytokine-cytokine receptor interaction pathway
PI3K-Akt signaling pathway pathway
Necroptosis pathway
Osteoclast differentiation pathway
Toll-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Chagas disease (American trypanosomiasis) pathway
Tuberculosis pathway
Hepatitis C pathway
Hepatitis B pathway
Measles pathway
Influenza A pathway
Human papillomavirus infection pathway
Kaposi's sarcoma-associated herpesvirus infection pathway
Herpes simplex infection pathway
INOH
GPCR signaling-cholera toxin-.owl pathway
GPCR signaling-G alpha s Epac and ERK-.owl pathway
GPCR signaling-pertussis toxin-.owl pathway
GPCR signaling-G alpha q-.owl pathway
GPCR signaling-G alpha i-.owl pathway
GPCR signaling-G alpha s PKA and ERK-.owl pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Cellular responses to external stimuli pathway
TRAF3-dependent IRF activation pathway pathway
Cellular responses to stress pathway
Factors involved in megakaryocyte development and platelet production pathway
Immune System pathway
Oxidative Stress Induced Senescence pathway
Hemostasis pathway
Interferon Signaling pathway
Innate Immune System pathway
Interferon alpha/beta signaling pathway
Cellular Senescence pathway
DDX58/IFIH1-mediated induction of interferon-alpha/beta pathway
Cytokine Signaling in Immune system pathway
Regulation of IFNA signaling pathway
TRAF6 mediated IRF7 activation pathway
KEGG
Cytokine-cytokine receptor interaction pathway
PI3K-Akt signaling pathway pathway
Necroptosis pathway
Osteoclast differentiation pathway
Toll-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Chagas disease (American trypanosomiasis) pathway
Tuberculosis pathway
Hepatitis C pathway
Hepatitis B pathway
Measles pathway
Influenza A pathway
Human papillomavirus infection pathway
Kaposi's sarcoma-associated herpesvirus infection pathway
Herpes simplex infection pathway
INOH
GPCR signaling-cholera toxin-.owl pathway
GPCR signaling-G alpha s Epac and ERK-.owl pathway
GPCR signaling-pertussis toxin-.owl pathway
GPCR signaling-G alpha q-.owl pathway
GPCR signaling-G alpha i-.owl pathway
GPCR signaling-G alpha s PKA and ERK-.owl pathway
PID NCI
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt P01575
TrEMBL Q0VE17
UniProt Splice Variant
Entrez Gene 15977
UniGene
RefSeq NM_010510
OMIM
CCDS CCDS18318
HPRD
IMGT
MGI ID MGI:107657
MGI Symbol Ifnb1
EMBL BC119395 BC119397 CH466527 K00020 X14029 X14455
GenPept AAA37891 AAI19396 AAI19398 CAA32190 CAA32625 EDL30977
RNA Seq Atlas 15977