InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PELI3

Summary

InnateDB Gene

IDBG-644402.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PELI3

Gene Name

E3 ubiquitin-protein ligase pellino homolog 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021097

Encoded Proteins

IDBP-697038

pellino homolog 3 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 17997719

[Homo sapiens] PELI3 and other pellino isoforms are the E3 ubiquitin ligases that mediate the IL-1-stimulated formation of K63-pUb-IRAK1 in cells, which may contribute to the activation of IKBKB and NF-kappaB, as well as other signalling pathways dependent on IRAK1 and IRAK4.

PMID 25483963

[Homo sapiens] Autophagy causes PELI3 degradation during Tlr4-signalling, subsequently inhibiting Il1b expression and impairing the hyperinflammatory phase during sepsis.

PMID 26310831

[Homo sapiens] PELI3 is involved in endotoxin tolerance and functions as a negative regulator of TLR2/4 signalling.

PMID 26310831

[Mus musculus] Peli3 is involved in endotoxin tolerance and functions as a negative regulator of Tlr2/4 signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174516:
The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:45153624-45162953

Strand

Forward strand

Band

Transcripts

ENSBTAT00000028102

ENSBTAP00000028102

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0008063	Toll signaling pathway
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0031397	negative regulation of protein ubiquitination
GO:0032480	negative regulation of type I interferon production
GO:0045751	negative regulation of Toll signaling pathway
GO:0050829	defense response to Gram-negative bacterium
GO:0070428	regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070534	protein K63-linked ubiquitination
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway