InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CLOCK

Summary

InnateDB Gene

IDBG-642395.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLOCK

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000044044

Encoded Proteins

IDBP-694879

clock homolog (mouse)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:72574278-72633079

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000061480

ENSBTAP00000053232

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001047	core promoter binding
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004402	histone acetyltransferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0007623	circadian rhythm
GO:0032922	circadian regulation of gene expression
GO:0042634	regulation of hair cycle
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050796	regulation of insulin secretion
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051775	response to redox state
GO:0071479	cellular response to ionizing radiation
GO:2000074	regulation of type B pancreatic cell development
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0033391	chromatoid body
GO:0043231	intracellular membrane-bounded organelle