Version 5.4
Bos taurus Gene: BT.37218
Summary
InnateDB Gene IDBG-642251.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.37218
Gene Name nuclear pore complex protein Nup50
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017652
Encoded Proteins
IDBP-694691
nuclear pore complex protein Nup50
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000093000:
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:116316367-116335303
Strand Forward strand
Band
Transcripts
ENSBTAT00000023480 ENSBTAP00000023480
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0046907 intracellular transport
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000093000
View Gene Order
ENSMUSG00000016619
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_115831
ISG15 antiviral mechanism pathway
REACT_6804
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
REACT_212
Glucose transport pathway
REACT_9441
Hexose transport pathway
REACT_9395
Nuclear import of Rev protein pathway
REACT_7991
Vpr-mediated nuclear import of PICs pathway
REACT_6190
Rev-mediated nuclear export of HIV RNA pathway
REACT_6354
Viral Messenger RNA Synthesis pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_6167
Influenza Infection pathway
REACT_6757
Interactions of Vpr with host cellular proteins pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_267668
Transcriptional regulation by small RNAs pathway
REACT_163931
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_25229
Interferon Signaling pathway
REACT_115566
Cell Cycle pathway
REACT_6900
Immune System pathway
REACT_910
M Phase pathway
REACT_6256
HIV Life Cycle pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_6185
HIV Infection pathway
REACT_6145
Influenza Life Cycle pathway
REACT_111217
Metabolism pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_6916
Interactions of Rev with host cellular proteins pathway
REACT_71
Gene Expression pathway
REACT_160255
Nuclear Envelope Breakdown pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_12472
Regulatory RNA pathways pathway
REACT_196648
Nuclear Envelope Breakdown pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_189085
Disease pathway
REACT_196650
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_204192
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
REACT_188804
Cell Cycle pathway
REACT_188937
Metabolism pathway
REACT_241408
M Phase pathway
REACT_270446
Transcriptional regulation by small RNAs pathway
REACT_253543
Glucose transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_240125
Hexose transport pathway
REACT_203949
Glycogen storage diseases pathway
REACT_233572
Gene Expression pathway
REACT_206535
Regulatory RNA pathways pathway
REACT_250557
Mitotic Prophase pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
hsa03013
RNA transport pathway
mmu03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MZD9
UniProt Splice Variant
Entrez Gene 506836
UniGene Bt.37218
RefSeq NM_001038048
HUGO HGNC:8065
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02014927
GenPept
RNA Seq Atlas 506836

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca