Version 5.4
Bos taurus Gene: BT.78028
Summary
InnateDB Gene IDBG-641855.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.78028
Gene Name transcription factor E2F1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003971
Encoded Proteins
IDBP-694261
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21131441
[Homo sapiens] E2F1 is important for normal inflammatory response to systemic LPS by enhancing the production of IL6 and TNFA in macrophages. (Demonstrated in murine model)
PMID 22310660
[Homo sapiens] E2F1 directly binds to the promoter of TLR3 to inhibit transcription. (Demonstrated in mice)
PMID 21131441
[Mus musculus] E2f1 is important for normal inflammatory response to systemic LPS by enhancing the production of Il6 and Tnfa in murine macrophages.
PMID 22310660
[Mus musculus] E2f1 directly binds to the promoter of Tlr3 to inhibit transcription.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101412:
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:63705710-63714008
Strand Reverse strand
Band
Transcripts
ENSBTAT00000005182 ENSBTAP00000005182
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 147 interaction(s) predicted by orthology.
Predicted by orthology
Total 147 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010628 positive regulation of gene expression
GO:0030900 forebrain development
GO:0043276 anoikis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048146 positive regulation of fibroblast proliferation
GO:0048255 mRNA stabilization
GO:0051726 regulation of cell cycle
GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:1990086 lens fiber cell apoptotic process
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0035189 Rb-E2F complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000101412
View Gene Order
ENSMUSG00000027490
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1181
Association of licensing factors with the pre-replicative complex pathway
REACT_1707
CDC6 association with the ORC:origin complex pathway
REACT_2243
Assembly of the pre-replicative complex pathway
REACT_111214
G0 and Early G1 pathway
REACT_683
G1/S-Specific Transcription pathway
REACT_329
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_1915
G2 Phase pathway
REACT_118568
Pre-NOTCH Transcription and Translation pathway
REACT_1194
Activation of NOXA and translocation to mitochondria pathway
REACT_121
Activation of PUMA and translocation to mitochondria pathway
REACT_383
DNA Replication pathway
REACT_1590
G1 Phase pathway
REACT_120956
Cellular responses to stress pathway
REACT_169325
Oncogene Induced Senescence pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_115566
Cell Cycle pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_169274
Cellular Senescence pathway
REACT_299
Signaling by NOTCH pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_829
Regulation of DNA replication pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_260005
G1 Phase pathway
REACT_208887
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
REACT_227891
G2 Phase pathway
REACT_232628
DNA Replication pathway
REACT_199110
G0 and Early G1 pathway
REACT_188804
Cell Cycle pathway
REACT_258573
Cyclin D associated events in G1 pathway
REACT_259974
CDC6 association with the ORC:origin complex pathway
REACT_255479
Regulation of DNA replication pathway
REACT_245528
M/G1 Transition pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_262002
Association of licensing factors with the pre-replicative complex pathway
REACT_253002
G1/S Transition pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_198608
G1/S-Specific Transcription pathway
REACT_206830
E2F mediated regulation of DNA replication pathway
REACT_235483
DNA Replication Pre-Initiation pathway
REACT_230841
Assembly of the pre-replicative complex pathway
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa04110
Cell cycle pathway
hsa05218
Melanoma pathway
hsa05219
Bladder cancer pathway
hsa05214
Glioma pathway
hsa05222
Small cell lung cancer pathway
hsa05215
Prostate cancer pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa05200
Pathways in cancer pathway
mmu05219
Bladder cancer pathway
mmu05218
Melanoma pathway
mmu04110
Cell cycle pathway
mmu05214
Glioma pathway
mmu05222
Small cell lung cancer pathway
mmu05215
Prostate cancer pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05223
Non-small cell lung cancer pathway
mmu05212
Pancreatic cancer pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
hes_heypathway
Notch-mediated HES/HEY network
p75ntrpathway
p75(NTR)-mediated signaling
e2f_pathway
E2F transcription factor network
il2_pi3kpathway
IL2 signaling events mediated by PI3K
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL E1BG94
UniProt Splice Variant
Entrez Gene 535369
UniGene Bt.78028
RefSeq NM_001206079
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02036488
GenPept
RNA Seq Atlas 535369

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca